Results 111 to 120 of about 1,148,279 (386)

Electrical Control of the Transduction Channels’ Gating Force in Mechanosensory Hair Cells

open access: yesAdvanced Science, EarlyView.
The inner ear's hair cells rely on mechanosensitive ion channels to convert vibrations of their hair‐bundle into electrical signals. We show that varying the electrical potential (U) across the sensory epithelium modulates a key determinant of mechanosensitivity—the gating force (FG)—by modulating the gating swing (d), ranging from the size of the ...
Achille Joliot   +2 more
wiley   +1 more source

Can children with speech difficulties process an unfamiliar accent? [PDF]

open access: yes, 2001
This study explores the hypothesis that children identified as having phonological processing problems may have particular difficulty in processing a different accent. Children with speech difficulties (n = 18) were compared with matched controls on four
Nathan, L., Wells, B.
core   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

open access: yesAdvanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang   +15 more
wiley   +1 more source

Management of tegmen defects with mastoid and epitympanic obliteration using S53P4 bioactive glass

open access: yesLaryngoscope Investigative Otolaryngology, 2020
Objective To evaluate the surgical results and complications in a cohort of patients operated on to repair a tegmen bony defect using either transmastoid approach with obliteration using S53P4 bioactive glass granules (TMA‐O), or the classic middle ...
Françoise Remangeon   +7 more
doaj   +1 more source

Can meaningful effective connectivities be obtained between auditory cortical regions? [PDF]

open access: yes, 2001
Structural equation modelling (SEM) of neuroimaging data can be evaluated both for the goodness of fit of the model and for the strength of path coefficients (as an index of effective connectivity).
Gonçalves, MS   +3 more
core   +2 more sources

The Geometry of Layer 2/3 Cortical Sound Processing in Slow Wave Sleep

open access: yesAdvanced Science, EarlyView.
Sleep is associated with a sensory disconnection whose mechanisms remain elusive. Large neuronal population recordings in the auditory cortex revealed that, in NREM sleep, the neural code for sounds is highly similar to wakefulness, but coordinated modulations of neuron responsiveness intermittently disconnect the local cortical networks from sensory ...
Allan Muller   +3 more
wiley   +1 more source

Aging affects the balance of neural entrainment and top-down neural modulation in the listening brain

open access: yesNature Communications, 2017
The changes that accompany age-related decreases in speech comprehension are not yet understood. Here, authors show that older adults are less able to entrain to speech-paced auditory rhythms and that the behavioural consequences can be counteracted by ...
Molly J. Henry   +3 more
doaj   +1 more source

New insights into cochlear sound encoding [version 1; referees: 2 approved]

open access: yesF1000Research, 2016
The inner ear uses specialized synapses to indefatigably transmit sound information from hair cells to spiral ganglion neurons at high rates with submillisecond precision.
Tobias Moser, Christian Vogl
doaj   +1 more source

Representation of Sound Categories in Auditory Cortical Maps [PDF]

open access: yes, 2002
We used functional magnetic resonance imaging (fMRI) to investigate the representation of sound categories in human auditory cortex. Experiment 1 investigated the representation of prototypical and non-prototypical examples of a vowel sound. Listening to
Ghosh, Satrajit   +3 more
core   +1 more source

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