Results 121 to 130 of about 1,148,279 (386)
Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors
Advanced Science, EarlyView.Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen +8 more
wiley +1 more source
Relating age and hearing loss to monaural, bilateral, and binaural temporal sensitivity
Frontiers in Neuroscience, 2014 Older listeners are more likely than younger listeners to have difficulties in making temporal discriminations among auditory stimuli presented to one or both ears.
Frederick J. Gallun +9 more
doaj +1 more source
Subicular Astrocytes Govern Seizure‐Impaired Fear Memory
Advanced Science, EarlyView.Astrocytes in dorsal subiculum act as a critical modulator of seizure‐associated cognitive dysfunction, operating through a Ca2+‐dependent adenosine‐linked astrocyte‐neuron signaling pathway that disrupts neuronal circuit homeostasis. This research highlights the potential of astrocyte‐targeted interventions as a therapeutic strategy, moving beyond the
Yuying Shao +15 more
wiley +1 more source
Multi-rate modulation encoding via unsupervised learning for audio event detection
EURASIP Journal on Audio, Speech, and Music ProcessingTechnologies in healthcare, smart homes, security, ecology, and entertainment all deploy audio event detection (AED) in order to detect sound events in an audio recording.
Sandeep Reddy Kothinti, Mounya Elhilali
doaj +1 more source
eLife, 2018 The brainstem’s lateral superior olive (LSO) is thought to be crucial for localizing high-frequency sounds by coding interaural sound level differences (ILD).
Tom P Franken +2 more
doaj +1 more source
NAVIS: Neuromorphic Auditory VISualizer Tool [PDF]
, 2017 This software presents diverse utilities to perform the first post-processing layer taking the neuromorphic auditory sensors (NAS) information. The used NAS implements in FPGA a cascade filters architecture, imitating the behavior of the basilar membrane
Domínguez Morales, Juan Pedro +3 more
core
XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss
Advanced Science, EarlyView.Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan +13 more
wiley +1 more source
Endocannabinoid Modulation of Stimulus-Specific Adaptation in Inferior Colliculus Neurons of the Rat
Scientific Reports, 2017 Cannabinoid receptors (CBRs) are widely distributed in the brain, including the inferior colliculus (IC). Here, we aim to study whether endocannabinoids influence a specific type of neuronal adaptation, namely, stimulus-specific adaptation (SSA) found in
C. Valdés-Baizabal +3 more
doaj +1 more source
Time is of the essence for auditory scene analysis
eLife, 2013 Using computational models and stimuli that resemble natural acoustic signals, auditory scientists explore how we segregate competing streams of sound.
Andrew R Dykstra, Alexander Gutschalk
doaj +1 more source
A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness
Advanced Science, EarlyView.Disorders of consciousness after severe brain injury are marked by reduced complexity of brain activity and limited treatment options. Using personalized whole‐brain models, this study shows that simulated lysergic acid diethylamide (LSD) and psilocybin shift patient brain dynamics closer to criticality.
Naji L.N. Alnagger +17 more
wiley +1 more source