Results 301 to 310 of about 645,742 (397)

Transtympanic Injection of Antioxidant‐Eluting Microparticles for Otoprotection From Cisplatin Toxicity in a Mouse Model

open access: yesOtolaryngology–Head and Neck Surgery, Volume 173, Issue 5, Page 1228-1235, November 2025.
Abstract Objective Cisplatin is a chemotherapeutic agent with the undesirable side effect of ototoxicity. Transtympanic injections of antioxidant formulations may provide local otoprotection. We tested a novel antioxidant‐eluting microparticle for its otoprotective capability from systemic cisplatin as measured by cochlear electrophysiology.
Eric Michael Smith   +3 more
wiley   +1 more source

Severe Hearing Loss in Children With Central Nervous System Tumors: A Population‐Based Cancer in Young People in Canada (CYP‐C) Report

open access: yesPediatric Blood &Cancer, Volume 72, Issue 11, November 2025.
ABSTRACT Purpose Children with central nervous system (CNS) tumors are prone to treatment‐related hearing loss (HL) and subsequent functional impairment. This study reports a dedicated population‐based analysis of CNS tumor‐specific rates and predictors of early severe HL.
Hallie Coltin   +13 more
wiley   +1 more source

Postoperative Radiotherapy for pT1- and pT2-Classified Squamous Cell Carcinoma of the External Auditory Canal. [PDF]

open access: yesCancers (Basel)
Nabuurs CH   +22 more
europepmc   +1 more source

Risk Factors for Hearing Loss Are Comparable in Preterm Versus Term Children: A Systematic Review

open access: yesActa Paediatrica, Volume 114, Issue 11, Page 2763-2782, November 2025.
ABSTRACT Aim Hearing loss occurs more frequently in preterm children. However, the influence of prematurity itself is unclear. We examined whether risk factors for hearing loss differ between preterm and term infants. Methods We conducted a systematic search of three databases in March 2023 for studies comparing risk factors for hearing loss in preterm
Pauline Roehrs   +4 more
wiley   +1 more source

Generation and Auditory Phenotypic Characterization of Prps1 p.Ala87Thr Mouse Knock‐In Model for Human DFNX1 Deafness

open access: yesClinical Genetics, Volume 108, Issue 5, Page 566-575, November 2025.
Our mouse model with a c.259G>A transition in PRPS1 showed a significant decrease in the number of hair cells and SGN counts at 48 weeks of age and a reduction in Prps1 enzymatic activity in the KI mouse. This model will serve as a valuable tool for developing therapeutic strategies.
Denise Yan   +6 more
wiley   +1 more source

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