Results 61 to 70 of about 69,276 (295)

Possibilities of Inner Ear Barrier Models for Otologic Drug Development

Advanced Therapeutics, EarlyView.
This review examines innovative organ chip models that reconstruct critical inner ear barriers, addressing a fundamental challenge in otologic drug development: the limited understanding of pharmaceutical behavior across these complex barriers. By replicating these barriers, the advanced models offer promising alternatives to traditional testing ...
Yeji Ahn, Seonmin Choi, Minju Kim, Zachary Estlack, Daniel Brown, Jaehong Key, Young Joon Seo, Jungkyu Kim   +7 more
wiley   +1 more source

Evaluation of Subtle Auditory Impairments with Multiple Audiological Assessments in Normal Hearing Workers Exposed to Occupational Noise

Brain Sciences, 2023
Recent studies involving guinea pigs have shown that noise can damage the synapses between the inner hair cells and spiral ganglion neurons, even with normal hearing thresholds—which makes it important to investigate this kind of impairment in humans ...
Alessandra Giannella Samelli, Clayton Henrique Rocha, Mariana Keiko Kamita, Maria Elisa Pereira Lopes, Camila Quintiliano Andrade, Carla Gentile Matas   +5 more
doaj   +1 more source

Brain‐Wide Spatiotemporally Distinct Traveling Waves Drive Anxiety‐Like Behaviors in Mice

Advanced Science, EarlyView.
J.Liu et al. reveal the complete propagation dynamics of cortical traveling waves, from local circuitry initiation to long‐range propagation, and identify their functional relevance in modulating anxiety‐like behaviors and underlying cellular neuroplasticity in mice.
Jiaming Liu, Jia‐Wen Mo, Xunda Wang, Yinuo Ma, Shile Tian, Qi Wang, Peng‐Li Kong, Ziqi An, Li Ding, Jing Ren, Cheng‐Lin Lu, Chuanjun Tong, Ed X. Wu, Qiu‐gen Hu, Xiong Cao, Yanqiu Feng   +15 more
wiley   +1 more source

A Retrospective Study of the Effects of Traumatic Brain Injury on Auditory Function: From a Clinical Perspective

NeuroSci, 2022
Purpose: The main purpose of this retrospective study was to identify auditory dysfunctions related to traumatic brain injury (TBI) in individuals evaluated in an Audiology clinic.
Mira White, Fauve Duquette-Laplante, Benoît Jutras, Caryn Bursch, Amineh Koravand   +4 more
doaj   +1 more source

Cracking the Valence Code: Patterned Facial Kinematics and Neural Signatures of Emotional Expressions in Mice

Advanced Science, EarlyView.
An AI‐powered system decodes emotional valence from mouse facial expressions, identifying ear dynamics as key indicators. By integrating facial kinematics with synchronized neural recordings, this approach establishes a direct link between behavior and brain activity, advancing automated emotion recognition in animal models.
Yujia Chen, Ruiqing Hou, Zhinan Chen, Junli Lu, Si Chen, Shisheng Xiong, Jianfeng Feng, Trevor W. Robbins, Haitao Yan, Xiao Xiao   +9 more
wiley   +1 more source

A Replicable and Generalizable Neuroimaging‐Based Indicator of Pain Sensitivity Across Individuals

Advanced Science, EarlyView.
Humans differ in their sensitivity to pain. With six large and diverse fMRI datasets (total N = 1046), this study finds that such individual differences in pain sensitivity can be tracked by fMRI responses to painful stimuli. A highly generalizable machine learning model is further built to predict pain sensitivity across all datasets and analgesic ...
Li‐Bo Zhang, Xue‐Jing Lu, Hui‐Juan Zhang, Zhao‐Xing Wei, Ya‐Zhuo Kong, Yi‐Heng Tu, Gian Domenico Iannetti, Li Hu   +7 more
wiley   +1 more source

BROAD‐NESS Uncovers Dual‐Stream Mechanisms Underlying Predictive Coding in Auditory Memory Networks

Advanced Science, EarlyView.
BROADband Network Estimation via Source Space (BROAD‐NESS) is a flexible analytical pipeline for identifying large‐scale brain networks from event‐related, source‐reconstructed MEG data, with a focus on auditory predictive and memory processes. BROAD‐NESS integrates a suite of complementary tools, including PCA‐based decomposition, phase space, and ...
Leonardo Bonetti, Gemma Fernández‐Rubio, Mathias H. Andersen, Chiara Malvaso, Francesco Carlomagno, Claudia Testa, Peter Vuust, Morten L. Kringelbach, Mattia Rosso   +8 more
wiley   +1 more source

Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain‐Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model

Advanced Science, EarlyView.
This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang, Yanran Zhang, Jialin Si, Honghui Mao, Feng He, Jin Ning, Guaiguai Ma, Xiaohua Chen, Haoxiang Xiao, Yuanyuan Zhu, Haifeng Zhang, Yifan Lu, Qian Liu, Meng Nian, Shiquan Sun, Shibin Yu, Shengxi Wu, Ze Fan, Zuolin Jin, Jing Huang   +19 more
wiley   +1 more source

A hierarchy of event-related potential markers of auditory processing in disorders of consciousness

NeuroImage: Clinical, 2016
Functional neuroimaging of covert perceptual and cognitive processes can inform the diagnoses and prognoses of patients with disorders of consciousness, such as the vegetative and minimally conscious states (VS;MCS).
Steve Beukema, Laura E. Gonzalez-Lara, Paola Finoia, Evelyn Kamau, Judith Allanson, Srivas Chennu, Raechelle M. Gibson, John D. Pickard, Adrian M. Owen, Damian Cruse   +9 more
doaj   +1 more source

Treating Hearing Loss: From Cochlear Implantation to Gene Therapy

Advanced Science, EarlyView.
Cochlear implantation is the primary treatment for deafness, restoring functional hearing in over a million people. Recently, gene therapy has enabled biological hearing restoration in a small number of patients with OTOF‐related mutations. This perspective evaluates both approaches, concluding that cochlear implants will remain the standard for most ...
Fan‐Gang Zeng, Jieyu Qi, Chen‐Chi Wu, Yilai Shu, Renjie Chai   +4 more
wiley   +1 more source