Results 71 to 80 of about 133,997 (277)

Role of N-methyl-D-aspartate receptors in action-based predictive coding deficits in schizophrenia [PDF]

, 2017
Published in final edited form as:Biol Psychiatry. 2017 March 15; 81(6): 514–524. doi:10.1016/j.biopsych.2016.06.019.BACKGROUND: Recent theoretical models of schizophrenia posit that dysfunction of the neural mechanisms subserving predictive coding ...
Ford, Judith M., Gunduz-Bruce, Handan, Jaeger, Judith, Kort, Naomi S., Krystal, John H., Mathalon, Daniel H., Reinhart, Robert M.G., Roach, Brian J.   +7 more
core   +1 more source

Genetic Diagnosis and Discovery Enabled by Large Language Models

Advanced Science, EarlyView.
We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu, Khaled Saab, Weida Liu, Zhouqing Fang, Zhuanfen Cheng, Svetolik Spasic, Maja Djurisic, Hiroaki Mohri, Wenlong Ren, Anil Palepu, Juraj Gottweis, Alan Karthikesalingam, Kavita Kulkarni, Annalisa Pawlosky, Devon Bonner, Elijah Kravets, Shruti Marwaha, Hector R. Mendez, Matthew T. Wheeler, Jonathan A. Bernstein, Undiagnosed Diseases Network, Cheng‐Yu Tsai, Chen‐Chi Wu, Konstantina M. Stankovic, Vivek Natarajan, Gary Peltz   +25 more
wiley   +1 more source

Quantifying the resolution of spatial and temporal representation in children with 22q11.2 deletion syndrome. [PDF]

, 2019
ObjectivesOur ability to generate mental representation of magnitude from sensory information affects how we perceive and experience the world. Reduced resolution of the mental representations formed from sensory inputs may generate impairment in the ...
Amato, Michele, Cabaral, Margarita H, Cruz, Joshua, Durdle, Courtney, Harvey, Danielle, McCabe, Kathryn L, Popa, Abbie M, Simon, Tony J, Tartaglia, Nicole, Wong, Ling M   +9 more
core   +1 more source

Spatial Transcriptomics of TMJ Reveals a Remodeling Fibroblast‐Immune Microenvironment Driving Arthritis Pain

Advanced Science, EarlyView.
Spatial transcriptomics reveals a remodeled fibroblast‐immune microenvironment in the temporomandibular joint (TMJ) during arthritis. By combining seqFISH with genetic mouse models, this study uncovers TMJ spatial cell atalas, macrophage‐fibroblast crosstalk, and cytokine signaling pathways driving TMJ inflammation and pain.
Ziying Lin, Supawadee Jariyasakulroj, Yang Shu, Jingyi Chen, Qing Chang, Pao‐Fen Ko, Yuyueyang Qiu, Feixiang Chen, David Ahn, Zhen Zhao, Jian‐Fu Chen   +10 more
wiley   +1 more source

Influence of the degree of hearing impairment on central auditory processing in people with presbycusis

The Egyptian Journal of Otolaryngology
Background Auditory processing involves decoding auditory impulses along auditory pathways in the central nervous system. Aging causes a decline in hearing and auditory processing abilities.
Marija Veletić, Sanja Đoković, Tamara Kovačević, Ljubica Isaković, Marija Bjelić   +4 more
doaj   +1 more source

Traceless Regulation of Genetic Circuitry

Advanced Science, EarlyView.
Energy‐based, as opposed to molecular, control offers unprecedented improvements in key circuit parameters. This review summarizes the fundamentals of such traceless switches, categorizes them by trigger modalities, and compares and contrasts distinct advantages as well as shortcomings of each kind.
Gokberk Unal, Martin Fussenegger
wiley   +1 more source

Rehabilitation Approaches for Drug Abuse, Addiction and Pediatric Issues

Iranian Rehabilitation Journal, 2015
The current issue of the Iranian Rehabilitation Journal contains original research evaluating the efficacy of addiction rehabilitation an evaluation of a child rehabilitation system for community based research, reading program for children with down ...
Asghar Dadkhah
doaj  

Normal Evoked Response to Rapid Sequences of Tactile Pulses in Autism Spectrum Disorders

Frontiers in Human Neuroscience, 2016
Autism spectrum disorder (ASD) is a developmental disorder diagnosed behaviorally, with many documented neurophysiological abnormalities in cortical response properties.
Santosh Ganesan, Sheraz Khan, Keri-Lee Garel, Matti S. Hämäläinen, Tal Kenet   +4 more
doaj   +1 more source

Visual illusions: An interesting tool to investigate developmental dyslexia and autism spectrum disorder [PDF]

, 2016
A visual illusion refers to a percept that is different in some aspect from the physical stimulus. Illusions are a powerful non-invasive tool for understanding the neurobiology of vision, telling us, indirectly, how the brain processes visual stimuli ...
Facoetti, Andrea, Gori, Simone, Molteni, Massimo   +2 more
core   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source