Results 71 to 80 of about 134,044 (293)

AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells

Advanced Science, EarlyView.
Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu, Guisheng Chen, Rui Hu, Peiwen Liu, Jintao Lou, Wenji Zhao, Zuhong He, Suhua Sha, Yiqing Zheng   +8 more
wiley   +1 more source

Audio Spectrogram Factorization for Classification of Telephony Signals below the Auditory Threshold [PDF]

arXiv, 2018
Traffic Pumping attacks are a form of high-volume SPAM that target telephone networks, defraud customers and squander telephony resources. One type of call in these attacks is characterized by very low-amplitude signal levels, notably below the auditory threshold.
arxiv  

Objective estimation of sensory thresholds based on neurophysiological parameters [PDF]

, 2018
Reliable determination of sensory thresholds is the holy grail of signal detection theory. However, there exists no gold standard for the estimation of thresholds based on neurophysiological parameters, although a reliable estimation method is crucial for both scientific investigations and clinical diagnosis.
arxiv   +1 more source

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

Advanced Science, EarlyView.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei, Shiwei Qiu, Xue Gao, Lu Zheng, Yijin Chen, Ying Ma, Haifeng Feng, Jinyuan Yang, Guojie Dong, Huiyi Nie, Weihao Zhao, Xiaoge Li, Guangqin Wang, Wei Xiong, Pu Dai, Yongyi Yuan   +15 more
wiley   +1 more source

Stochastic undersampling steepens auditory threshold/duration functions: Implications for understanding auditory deafferentation and aging

Frontiers in Aging Neuroscience, 2015
It has long been known that some listeners experience hearing difficulties out of proportion with their audiometric losses. Notably, some older adults as well as auditory neuropathy patients have temporal-processing and speech-in-noise intelligibility ...
Frederic eMarmel, Frederic eMarmel, Medardo A Rodríguez-Mendoza, Enrique A Lopez-Poveda, Enrique A Lopez-Poveda, Enrique A Lopez-Poveda   +5 more
doaj   +1 more source

Why early tactile speech aids may have failed: no perceptual integration of tactile and auditory signals [PDF]

arXiv, 2017
Tactile speech aids, though extensively studied in the 1980s and 90s, never became a commercial success. A hypothesis to explain this failure might be that it is difficult to obtain true perceptual integration of a tactile signal with information from auditory speech: exploitation of tactile cues from a tactile aid might require cognitive effort and so
arxiv  

GDC: Integration of Multi‐Omic and Phenotypic Resources to Unravel the Genetic Pathogenesis of Hearing Loss

Advanced Science, EarlyView.
Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng, Xuegang Wang, Mingjun Zhong, Jia Geng, Wenjian Li, Kanglu Pei, Jing Wang, Lanchen Wang, Yu Lu, Jing Cheng, Fengxiao Bu, Huijun Yuan   +11 more
wiley   +1 more source

Comparison of Gaps in noise test (GIN) in adults with normal and conductive hearing loss

مجله پژوهش در علوم توانبخشی, 2013
Introduction: conductive hearing loss attenuates and delays sound transmission in the middle ear. It can make variety of central auditory processing disorders; that persists even after resolve of peripheral auditory system problems. One of the aspects of
Mahya Sharifinik, Sima Tajik, Ghasem Mohammadkhani, Shohreh Jalaie   +3 more
doaj   +3 more sources

An Invertible Discrete Auditory Transform [PDF]

arXiv, 2004
A discrete auditory transform (DAT) from sound signal to spectrum is presented and shown to be invertible in closed form. The transform preserves energy, and its spectrum is smoother than that of the discrete Fourier transform (DFT) consistent with human audition. DAT and DFT are compared in signal denoising tests with spectral thresholding method. The
arxiv  

The Cochlear Tuning Curve [PDF]

, 2001
The tuning curve of the cochlea measures how large an input is required to elicit a given output level as a function of the frequency. It is a fundamental object of auditory theory, for it summarizes how to infer what a sound was on the basis of the cochlear output.
arxiv   +1 more source