Results 21 to 30 of about 81,801 (247)

Preparatory Knee Flexion-Extension Movements Enhance Rapid Sidestepping Performance in Collegiate Basketball Players

Frontiers in Sports and Active Living, 2021
Lower-limb weight-bearing load distribution in stationary standing influences the timing of rapid first step initiation of importance for functional movement activities and agility performance in sports.
Masahiro Fujimoto, Eri Uchida, Akinori Nagano, Mark W. Rogers, Tadao Isaka   +4 more
doaj   +1 more source

Can facet joint block be a complementary or alternative therapeutic option for patients with osteoporotic vertebral fractures: a meta-analysis

Journal of Orthopaedic Surgery and Research, 2022
Background Recently facet joint block has been increasingly used to relief the residual pain after vertebral augmentation, but whether it can be a complementary or alternative to vertebral augmentation remain largely unknown. Thus, we conducted this meta-
Zhi Chen, Chenyang Song, Jianwen Chen, Jun Sun, Wenge Liu   +4 more
doaj   +1 more source

Long-term experience in the treatment of α1-antitrypsin deficiency: 25 years of augmentation therapy [PDF]

European Respiratory Review, 2015
Although it is often under-recognised, α1-antitrypsin deficiency (AATD) represents one of the most common genetic respiratory disorders worldwide. Since the publication of studies in the late 1980s, which demonstrated that plasma-derived augmentation ...
Helmut Teschler
doaj   +1 more source

Exploring the causes of augmentation in restless legs syndrome

Frontiers in Neurology, 2023
Long-term drug treatment for Restless Legs Syndrome (RLS) patients can frequently result in augmentation, which is the deterioration of symptoms with an increased drug dose.
Pengyu Zeng, Pengyu Zeng, Tiantian Wang, Tiantian Wang, Lisan Zhang, Lisan Zhang, Fang Guo, Fang Guo   +7 more
doaj   +1 more source

Management of lung disease in alpha-1 antitrypsin deficiency: what we do and what we do not know

Therapeutic Advances in Chronic Disease, 2021
Management of lung disease in patients with alpha-1 antitrypsin deficiency (AATD) includes both non-pharmacological and pharmacological approaches. Lifestyle changes with avoidance of environmental pollutants, including tobacco smoke, improving exercise ...
Igor Barjaktarevic, Michael Campos
doaj   +1 more source

Frequency and Pattern of Worldwide Ocular Gene Therapy Clinical Trials up to 2022

Biomedicines, 2023
The purpose of this study is to describe worldwide gene therapy clinical trials aimed at treating ophthalmic disorders. Information regarding all worldwide clinical trials was collected through 15 different sources, including ClinicalTrials.gov.
Hossein Ameri, Niranjana Kesavamoorthy, Dara N. Bruce   +2 more
doaj   +1 more source

Recommendations for the Implementation of the Self-Administration of Alpha-1 Antitrypsin

International Journal of COPD, 2023
María Torres-Durán,1 José Luis López-Campos,2,3 Myriam Calle Rubio,4 Carmen Montero-Martínez,5 Ana Priegue Carrera,6 Rosanel Amaro Rodríguez,7 Miriam Barrecheguren,8 María Ángeles Barrio Guirado,9 Francisco Javier Callejas-González,10 Francisco Casas ...
Torres-Durán M, López-Campos JL, Calle Rubio M, Montero-Martínez C, Priegue Carrera A, Amaro Rodríguez R, Barrecheguren M, Barrio Guirado MA, Callejas-González FJ, Casas-Maldonado F, Diab-Cáceres L, García-Meseguer P, Hernández-Pérez JM, Lázaro-Asegurado L, Martínez-González C, Martínez Rivera C, Michel FJ, Montoro-Ronsano JB, Sánchez R, Ortiz-Pica M, Parra I, Quintero García JP, Ruiz-Serrano-de la Espada MDR, Tortajada-Goitia B, Miravitlles M   +24 more
doaj  

Alpha-1 Antitrypsin Augmentation Therapy Improves Survival in Severely Deficient Patients with Predicted FEV1 Between 10% and 60%: A Retrospective Analysis of the NHLBI Alpha-1 Antitrypsin Deficiency Registry

International Journal of COPD, 2020
Franck F Rahaghi,1 Richard Monk,2 Viswanathan Ramakrishnan,3 Tatsiana Beiko,2 Charlie Strange2 1Department of Pulmonary and Critical Care, Cleveland Clinic Florida, Weston, FL, USA; 2Division of Pulmonary, Critical Care, Allergy and Sleep Medicine ...
Rahaghi FF, Monk R, Ramakrishnan V, Beiko T, Strange C   +4 more
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Sustained high expression of human FVII following AAV8-mediated gene delivery in mice

Molecular Therapy: Methods & Clinical Development
Factor VII (FVII) deficiency is a rare bleeding disorder with a prevalence of approximately 1:300,000–500,000 individuals. We explored whether adeno-associated virus (AAV)-mediated gene therapy can achieve durable and functional expression of human FVII (
Andrea D’Amico, Bas Blits, Joëlle van den Herik, Fred de Winter, Paul H.P. Kaijen, Barbara Hobo, Alexander Henrik van Asbeck, Joost Verhaagen, David G.M. Mosmuller, Jan Voorberg   +9 more
doaj   +1 more source