Memantine as an Augmentation Therapy for Anxiety Disorders
Case Reports in Psychiatry, 2012 Objective. Glutamate, an excitatory neurotransmitter in the central nervous system (CNS), may play a role in the development of anxiety. Memantine partially blocks N-methyl-D-aspartate (NMDA) receptors' glutamate channels located in the CNS.
Thomas L. Schwartz +2 more
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Long-term experience in the treatment of α1-antitrypsin deficiency: 25 years of augmentation therapy [PDF]
European Respiratory Review, 2015 Although it is often under-recognised, α1-antitrypsin deficiency (AATD) represents one of the most common genetic respiratory disorders worldwide. Since the publication of studies in the late 1980s, which demonstrated that plasma-derived augmentation ...
Helmut Teschler
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Augmentation therapy in alpha-1 antitrypsin deficiency: advances and controversies
Therapeutic Advances in Respiratory Disease, 2010 Alpha-1 antitrypsin (AAT) deficiency is a hereditary condition characterized by low levels of AAT in plasma and hence diffusion into tissues. One of the most relevant characteristics of the disease is the development of panacinar emphysema due to an ...
Adriano R. Tonelli, Mark L. Brantly
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Frequency and Pattern of Worldwide Ocular Gene Therapy Clinical Trials up to 2022
Biomedicines, 2023 The purpose of this study is to describe worldwide gene therapy clinical trials aimed at treating ophthalmic disorders. Information regarding all worldwide clinical trials was collected through 15 different sources, including ClinicalTrials.gov.
Hossein Ameri +2 more
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Efficacy of alpha1-antitrypsin augmentation therapy in conditions other than pulmonary emphysema
Orphanet Journal of Rare Diseases, 2011 Up to now alpha 1-antitrypsin (AAT) augmentation therapy has been approved only for commercial use in selected adults with severe AAT deficiency-related pulmonary emphysema (i.e.
de Serres Frederick +2 more
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Biologics: Targets & Therapy, 2009 Irina Petrache1, Joud Hajjar1, Michael Campos21Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA; 2Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Miller School of Medicine ...
Irina Petrache +2 more
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Gene augmentation therapy attenuates retinal degeneration in a knockout mouse model of Fam161a retinitis pigmentosa. [PDF]
Mol Ther, 2023 Photoreceptor cell degeneration and death is the major hallmark of a wide group of human blinding diseases including age-related macular degeneration and inherited retinal diseases such as retinitis pigmentosa. In recent years, inherited retinal diseases
Matsevich C +9 more
europepmc +2 more sources
D-cycloserine augmentation in behavioral therapy for obsessive-compulsive disorder: a meta-analysis
Drug Design, Development and Therapy, 2015 Jing Xia,1 Yanqiu Du,2 Jiyang Han,1 Guo Liu,1 Xumei Wang11Department of Psychiatry, Shengjing Hospital of China Medical University, Heping District Shenyang, Liaoning, People’s Republic of China; 2Department of Medicine, Shenyang Ninth People’
Xia J, Du Y, Han J, Liu G, Wang X
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AAV-mediated gene augmentation therapy of CRB1 patient-derived retinal organoids restores the histological and transcriptional retinal phenotype [PDF]
Stem Cell Reports, 2023 Boon N +10 more
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Cellular immunity augmentation in mainstream oncologic therapy
Cancer Biology & Medicine, 2017 Anticancer immunotherapy has undergone a long evolving journey for decades, and has been dramatically applied to mainstream treatments in oncology in recent 5 years. This progress represents an advanced milestone following cytotoxic medicine and targeted
Daohong Chen, Xiaoshi Zhang
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