Results 181 to 190 of about 13,388 (244)

Straight to Phase III: Model‐Informed Approach Speeds Depemokimab Clinical Development in Interleukin‐5‐Driven Diseases

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 1005-1015, April 2026.
Straight to Phase III: Model‐informed approach speeds depemokimab clinical development in interleukin‐5‐driven diseases. IL‐5, a key mediator of type 2 inflammation, underlies various diseases, including severe asthma, CRSwNP, EGPA, and HES. Reduction in blood eosinophil count (BEC), a biomarker of IL‐5 activity, is commonly used to evaluate the ...
Chiara Zecchin, Stein Schalkwijk, Isabelle J. Pouliquen, Alienor Berges, Nicholas Bird, Richard Follows, Daren Austin   +6 more
wiley   +1 more source

Antiplatelet Therapy in Atrial Fibrillation Patients on Direct Oral Anticoagulants Undergoing Percutaneous Coronary Intervention: Which and How. [PDF]

J Clin Med
Martini L, Lisi M, Pompei G, Arioti M, Bendandi F, Henein MY, Cameli M, Rubboli A.   +7 more
europepmc   +1 more source

Brain Age Estimation on T2‐FLAIR Scans for Application to Multiple Sclerosis

Human Brain Mapping, Volume 47, Issue 5, 1 April 2026.
While the brain‐age paradigm has emerged as a promising biomarker of neurodegeneration in multiple sclerosis (MS), most available brain‐age prediction models are based on 3D‐T1w scans, which are not acquired in routine clinical practice. Leveraging a large multicentre collection of scans from healthy controls, we developed an accurate brain‐age ...
Jordan Colman, Giuseppe Pontillo, Olivia Goodkin, Michael A. Foster, Nima Mahmoudi, Mike P. Wattjes, Arturo Brunetti, Gabriel Gonzalez‐Escamilla, Sergiu Groppa, Einar August Høgestøl, Lars T. Westlye, Silvia Messina, Jacqueline Palace, Rosa Cortese, Nicola De Stefano, Àlex Rovira, Jaume Sastre‐Garriga, Stefan Ropele, Christian Enzinger, Maria A. Rocca, Massimo Filippi, Barbara Bellenberg, Carsten Lukas, Massimiliano Calabrese, Marco Castellaro, Tomas Uher, Manuela Vaneckova, Ahmed Toosy, Olga Ciccarelli, Tarek Yousry, Ferran Prados, Frederik Barkhof, James H. Cole, MAGNIMS Study Group, Frederik Barkhof, Nicola de Stefano, Jaume Sastre‐Garriga, Olga Ciccarelli, Christian Enzinger, Massimo Filippi, Claudio Gasperini, Cristina Granziera, Gabriele Deluca, Menno M. Schoonheim, Alex Rovira, Maria A. Rocca, Ahmed Toosy   +46 more
wiley   +1 more source

Prediction of coronary no-reflow from the surface electrocardiogram. [PDF]

Proc (Bayl Univ Med Cent)
Banchs JE.
europepmc   +1 more source

Risk of Occult Contralateral Neck Metastasis in Early‐Stage HPV‐Related Lateralized Cancer of the Base of the Tongue

Head &Neck, Volume 48, Issue 4, Page 986-993, April 2026.
ABSTRACT Objectives (1) To determine the incidence of occult contralateral cervical lymph node metastasis in patients with early‐stage HPV‐associated base‐of‐tongue (BOT) oropharyngeal squamous cell carcinoma (OPSCC) treated with primary surgery; and (2) to compare survival and recurrence in patients who did and did not undergo contralateral neck ...
Tyler R. Halle, Austin C. Cao, Anusha G. Naik, Gregory S. Weinstein, Jake J. Lee, Theodore A. Gobillot, Erin R. Kaye, Robert M. Brody, Devraj Basu, Bert W. O'Malley Jr, D. Gregory Farwell, Steven B. Cannady, Alexander Lin, John Lukens, Michelle Gentile, Jason G. Newman, Ara A. Chalian, Christopher H. Rasskeh, Karthik Rajasekaran   +18 more
wiley   +1 more source

Annotation of 200 Insect Genomes with BRAKER for Consistent Comparisons across Species. [PDF]

Sci Data
Saenko S, Hoff KJ, Stanke M.
europepmc   +1 more source

Paroxysmal Nocturnal Haemoglobinuria‐Associated Acute Cutaneous Thrombosis and Haemolysis in the Setting of Parvovirus B19 and Varicella Zoster Virus Infection

eJHaem, Volume 7, Issue 2, April 2026.
ABSTRACT A 28‐year‐old male with paroxysmal nocturnal haemoglobinuria (PNH) presented with headache, nasal bridge discomfort and haemoglobinuria. He developed a macular‐papular rash which rapidly progressed into purpura, necrosis and peri‐orbital oedema. Investigations demonstrated severe haemolytic anaemia and acute parvovirus B19 infection.
Louise J. Potter, Roochi Trikha, Shreyans Gandhi, Joanne Large, Tanya N. Basu, Jeanne Boissiere, Hannah Devine, Taku Sugai, Aushna Rasool, Austin Kulasekararaj   +9 more
wiley   +1 more source

Resistance gene enrichment sequencing refines the Brassica napus NLRome. [PDF]

Plant Physiol
Wu 吴家旭 J, Mukhopadhyay S, Pérez-López E.   +2 more
europepmc   +1 more source

Global Hydroclimatic Controls on Multithread River Dynamics

AGU Advances, Volume 7, Issue 2, April 2026.
Abstract Most large rivers in densely populated areas split flow into multiple channels, forming interconnected pathways called threads. Multithread rivers are sensitive to hydroclimatic changes, yet understanding their dynamics is challenging due to the lack of robust metrics to characterize their evolution.
Feifei Zhao, Vamsi Ganti, Austin Chadwick, Evan Greenberg, Jonah McLeod, Yinxue Liu, Louise Slater, Efi Foufoula‐Georgiou   +7 more
wiley   +1 more source

A haplotype-resolved gap-free chromosome assembly of the threatened plant Paradombeya sinensis. [PDF]

Sci Data
Tao L, Tang L, Chen Y, Sun W.
europepmc   +1 more source