Results 111 to 120 of about 101,027 (294)

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Aura

, 2020
This music score was submitted for the Kaleidoscope 2020 Call for Scores, an open access collaboration with the UCLA Music Library.
openaire   +3 more sources

Auras do Professar: desterritorialização da autoridade no sentido da communitas e do entusiasmo

Revista Brasileira de Estudos da Presença, 2020
O artigo caracteriza a autoridade docente como fruto da tradição patriarcal e cristã, na qual a performance do professor instaurava a disciplina e o silêncio. Mas, tal como a Aura da obra de arte entra em decadência pelo avanço técnico, o mesmo ocorreria
Pedro Luis Braga, Ana Cristina Zimmermann   +1 more
doaj  

CMOS‐Integrated Synaptic Photoreceptor Chip Inspired by Insect Visual Processing

Advanced Science, EarlyView.
CMOS‐integrated Si QDs/ReS2 synaptic photoreceptor array mimics the parallel processing and wavelength‐selective strategy of insect vision. By combining intrinsic ultraviolet‐violet sensitivity with synaptic plasticity, the chip enables frontend sensory redundancy reduction without external filters, offering a scalable pathway toward lowpower ...
Jian Chai, Xinyi Xu, Yue Wang, Xiaochen Wang, Hailiang Wang, Yunfei Xie, Xinwei Zhang, Haoyu Wang, Hao Ning, Jiangming Lin, Yongliang Xie, Qihai Jiang, Baoshi Qiao, Xiaolei Ding, Luyao Ma, Shukai Duan, Zhenyi Ni, Huan Hu, Xin He, Fei Xue, Feichi Zhou, Lingfei Li, Srikrishna Chanakya Bodepudi, Rui Yuan, Bin Yu, Yang Xu   +25 more
wiley   +1 more source

Prolonged visual aura, late-onset migraine-like headaches, and seizures suggest an occipital arteriovenous malformation

Journal of Family Medicine and Primary Care
To report a patient with occipital arteriovenous malformation (AVM), manifested by prolonged visual aura and migraine-like headache as well as rare tonic–clonic seizures. The patient is a 55-year-old woman with a left occipital, unruptured AVM that first
Josef Finsterer, Sounira Mehri
doaj   +1 more source

A Soft Mechanoluminescent Skin for High‐Resolution Optical Tactile Sensing in Human–Machine Interaction

Advanced Science, EarlyView.
A soft mechanoluminescent tactile sensor that converts force directly into light is presented, enabling imaging‐based, wiring‐free touch sensing. By integrating a flexible ML‐skin with CMOS readout, the system achieves high sensitivity, fast response, and high spatial resolution, while maintaining structural simplicity and energy efficiency, offering a
Yu Feng, Qiaojiao Wang, Yehui Liu, Jiankun Li, Senlin Hou, Xiaomeng Yang, Ziyi Li, Yanji Yi, Meng Chen, Guanglie Zhang, Hao Sun, Wen Jung Li   +11 more
wiley   +1 more source

Tumor‐Infiltrating mregDCs Restrain Anti‐Tumor Immunity in Early Relapse HCC

Advanced Science, EarlyView.
Tumor‐infiltrating mregDCs are regulated by the TNFR2‐non‐canonical NF‐κB axis, which is mediated by TNF‐α secreted by CD161+CD8+ T cells. These mregDCs recruit CD161+CD8+ T cells via the CCL20‐CCR6 axis, forming a positive feedback loop that enhances immunosuppression, promotes early recurrence of HCC, and further confirms TNFR2 as a key therapeutic ...
Zefan Zhang, Lin Ding, Yu Zhong, Haokang Feng, Linglong Huang, Waidong Huang, Chunqing Wang, Arne Östman, Beili Wang, Jian Zhou, Jia Fan, Wei Guo, Liang Wu, Yunfan Sun   +13 more
wiley   +1 more source

Poner el cuerpoEl Teatro Proletario de Cámara de Osvaldo Lamborghini: de las revistas porno de saldo a la impresión del cuerpo del artista en la obra

América
In his Catalan exile, the Argentine writer Osvaldo Lamborghini composed a strange device: Teatro Proletario de Cámara (c. 1985). Across the Atlantic Ocean, locked in an apartment in Barcelona, he worked on a volume of more than 500 pages made of all ...
Agustina Perez
doaj   +1 more source

Uncommitted Couples: Some Efficiency and Policy Implications of Marital Bargaining [PDF]

This paper studies a married couple's dynamic investment and consumption choices under the assumption that the couple cannot commit across time not to renegotiate their decisions. The inefficiencies that can arise are characterized. Efficiency properties
Saku Aura
core  

AurA C288 and AurA C275 constructs and protein sequence.

, 2014
(A) AurA C288 contains mutations T287A, T288C, C290A & C393A. (B) AurA C275 contains mutations F275C, C290A & C393A. (C) Sequence of AurA 122–403 kinase domain with N-terminal His-tag (underlined).
Julian Blagg (188170), Fiona Rowan (610317), Meirion Richards (421012), Marcella Widya (610318), Richard Bayliss (610319)   +4 more
core   +1 more source