Results 31 to 40 of about 583,239 (283)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Dijital Çağda Sanat Eserinin Biricikliği Üzerine

Bodrum Journal of Art and Design, 2022
Walter Benjamin’in “Mekanik Yeniden Üretim Çağında Sanat Eseri” metninde tartışmaya açtığı sanat yapıtının biricikliği sorunsalı, yeniden üretim tekniklerinin gelişmesi ve çeşitlenmesi dolayısıyla günümüz dijital çağında da geçerliliğini korumaktadır ...
Batu Bozoğlu, Eda Çekil Konrat
doaj  

Management of migraine [PDF]

, 1999
Migraine is a complex neurovascular disease characterised by episodic attacks of severe headache accompanied by autonomic and neurological symptoms. Two types of migraine have been identified: (1) common migraine, or migraine without aura, occurring in ...
Farrugia, Isabelle
core  

Pictures of the past : Benjamin and Barthes on photography. [PDF]

, 2002
This paper explores the key moments in Benjamin’s and Barthes’s analyses of the cultural significance of the photograph. For Benjamin these are; the optical unconscious, the transmission of aura, the representation of cultural and political decay and ...
Barthes, Roland, Barthes, Roland, Barthes, Roland, Barthes, Roland, Benjamin, Walter, Cadaver, Eduardo, Gilloch, Graeme, Graeme Gilloch, Konersmann, Ralf, Metz, Christian, Price, Mary, Rabaté, Jean-Michel, Sontag, Susan, Tim Dant, Virilio, Paul   +14 more
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Contemporary Misticism: Recovering Sensible Aesthetics in an Age of Digital Production

Religions, 2019
Materialist accounts of artistic development emphasize the ongoing revolution of media in the progress of history. Amongst the most popular accounts of modernity are Walter Benjamin’s essays on the relationship of photography to traditional art ...
Randall K. Van Schepen
doaj   +1 more source

Augmented Reality Urban Art. Dallo squatting urbano al museo diffuso

Ocula, 2023
The combination of Augmented Reality (AR) art and urban art has been at the centre of numerous experiments and pioneering aesthetic research that have progressively interpreted this medium as subversive and expressive.
Federico Biggio
doaj   +1 more source

ChemMatters: Special Issue on NASA's EOS Aura Mission (Sept. 2002) [PDF]

, 2002
: This ChemMAtters issue features the human side of NASA’s Aura mission with five articles that include interviews with Aura scientists and engineers. ChemMatters is a quarterly publication of the American Chemical Society (ACS) geared to a high school ...

core  

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source