Results 81 to 90 of about 35,719 (250)

Matrix Stiffness Induces Endothelial Network Senescence

Advanced Science, EarlyView.
Using a 3D human in vitro model that decouples mechanical stress from inflammatory or biochemical signals, matrix stiffening induces a senescence phenotype in endothelial networks. This mechano‐induced senescence activates Notch signaling, and pharmacologic Notch inhibition attenuates this stiffness‐induced senescence.
Jiyeon Song, Alexandra N. Rindone, Ya Guan, Connor D. Amelung, Prarthana Sanjay Daswani, Jennifer H. Elisseeff, Sharon Gerecht   +6 more
wiley   +1 more source

PDGFRα+/Integrin α2+ Fibroblasts Orchestrate Tumor Budding in Oral Squamous Cell Carcinoma via Mechano‐Metabolic Symbiosis: E‐Cadherin/Integrin α2β1 Adhesion and Mitochondrial Transfer

Advanced Science, EarlyView.
PDGFA/PDGFRα signaling recruits CAFs to OSCC nests, and CAF‐OSCC contact drives tumor budding invasion. Mechanistically, heterotypic adhesion via E‐cadherin/integrin α2β1 activates YAP signaling in OSCC cells, inducing EMT. Concurrently, CAFs transfer mitochondria through TNTs, supplying ATP to fuel invasion.
Yufang Liu, Jiao Li, Juan Liu, Qi Dong, Haoyang Zhang, Yanjin Wang, Huibing Li, Ye Guan, Lei Cao, Manqing Zhang, Fangning Guo, Xue Liu, Zhen Yang, Mengmeng Lu, Hui Liu, Laiping Zhong, Tong Ji, Tingjiao Liu   +17 more
wiley   +1 more source

Poner el cuerpoEl Teatro Proletario de Cámara de Osvaldo Lamborghini: de las revistas porno de saldo a la impresión del cuerpo del artista en la obra

América
In his Catalan exile, the Argentine writer Osvaldo Lamborghini composed a strange device: Teatro Proletario de Cámara (c. 1985). Across the Atlantic Ocean, locked in an apartment in Barcelona, he worked on a volume of more than 500 pages made of all ...
Agustina Perez
doaj   +1 more source

Direct Observation of Vortex Liquid Droplets in the Iron Pnictide Superconductor CaKFe4As4 at 0.5Tc

Advanced Science, EarlyView.
Vortex matter in the iron‐based superconductor CaKFe4As4${\rm CaKFe}_4{\rm As}_4$ is visualized at the nanoscale, revealing the unexpected emergence of vortex‐liquid droplets far below the critical temperature. These localized fluctuating regions coexist with a vortex solid, demonstrating that dissipation‐related dynamics arise well before macroscopic ...
Óscar Bou Marqués, Jose A. Moreno, Pablo García Talavera, Mingyu Xu, Juan Schmidt, Sergey L. Bud'ko, Paul C. Canfield, Isabel Guillamón, Edwin Herrera, Hermann Suderow   +9 more
wiley   +1 more source

Cycle of Use, Cracks and Aura in Contemporary Art: Conservation within Art Creation

CeROArt : Conservation, Exposition, Restauration d'Objets d'Art
The article focuses on the realization of the “Plafones” series by contemporary artist Gabriel de la Mora, whose creative process integrates ancient ceilings with the expertise of a conservator.
Asseneth Regis Vives
doaj   +1 more source

Multi‐Omics Profiling of High‐Grade Serous Ovarian Cancer Reveals an Inflammation‐Related Lipid Metabolism Subtype Associated With Platinum Resistance

Advanced Science, EarlyView.
Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao, Junyi Li, Bo Zheng, Wanshan Liu, Yaru Wang, Shufeng Wang, Ying Cui, Huiqin Guo, Hongxia Wang, Ting Xiao, Kun Qian, Jing Zuo   +11 more
wiley   +1 more source

Aurae

, 1892
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openaire   +1 more source

PolyG Fibrils Coalesce Into Nuclear Ribbons That Engage Proteostasis Machinery in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
In NIID, expanded NOTCH2NLC repeats give rise to nuclear polyG inclusions. Tracer‐guided in situ cryo‐electron tomography enables cross‐scale structural analysis from mouse brain to native neuronal nuclei, revealing dense‐core/peripheral‐halo inclusions built from compact polyG ribbons.
Hui Dong, Yongcheng Pan, Zhiyao Tang, Yuxuan Yao, Guicong Zhang, Junpu Wang, Haonan Xiao, Yun Tian, Beisha Tang, Dan Li, Qiang Guo, Ruijun Tian, Qiong Liu, Cong Liu   +13 more
wiley   +1 more source

Migraine - symptomatology, diagnostics, non-pharmacological and pharmacological procedures

Journal of Education, Health and Sport, 2018
Surprisingly, migraine is in the 3rd place of all diseases occurring in the world and affects 12% of the population, between the ages of 25 and 55. Migraine headaches significantly affect the quality of human life, while limiting proper bio-psycho-social
Kamila Tuzim, Magdalena Urbańczuk, Tomasz Tuzim, Marcin Urbańczuk, Katarzyna Schab, Marcin Lewicki   +5 more
doaj  

High‐Density E. Coli Cultivation Arrays for Combinatorial Drug Testing With Subsequent Lipid Profiling by MALDI‐MS

Advanced Science, EarlyView.
High‐throughput antibiotic cross‐gradient assays on microdroplet arrays. A multichannel printhead together with five pressure regulators forms droplet arrays of up to 20 832 droplets within 25 minutes. Each droplet contains unique concentrations of antibiotics, allowing to moniture a vast spectrum of bacterial repsonses over night. The bacterial growth
M. Breitfeld, C. L. Dietsche, F‐L. Born, I. Onipko, L. Blaase, P. S. Dittrich   +5 more
wiley   +1 more source