Zuranolone: A case study in (regulatory) rush to judgement?
Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove +4 more
wiley +1 more source
Design of Real Time Heart Rate Monitoring System With ARDUINO UNO R3 Based on Android Application [PDF]
The heart is an important organ for humans. Heart disease has claimed many lives. It happened because not everyone can do regular heart checks. High cost and time wasted could be the reason.
Pudy Astomo, Suryadi, Subari, Arkhan
core
ABSTRACT Neurological disorders represent a critical domain within global health, necessitating advanced interventions to address complex pathologies such as tumors, functional disorders, and cerebrovascular diseases. Despite the proven benefits of early intervention, current treatment paradigms face significant challenges: (1) limited precision in ...
Qing Ye +14 more
wiley +1 more source
Bryophytes from the Republic of Equatorial Guinea (West Central Africa) : 5., Diplasiolejeunea cogoensis sp. nov. [PDF]
Diplasiolejeunea cogoensis is described as new from Equatorial Guinea (West Central Africa). It is included in Sectio Villaumeae, it is recognisable by its big size, the auriculated dorsal base of lobe, its long and always double first tooth and the ...
Heras Pérez, Patxi +2 more
core
Alginate microspheres containing temperature sensitive liposomes (TSL) for MR-guided embolization and triggered release of doxorubicin [PDF]
Objective The objective of this study was to develop and characterize alginate microspheres suitable for embolization with on-demand triggered doxorubicin (DOX) release and whereby the microspheres as well as the drug releasing process can be visualized ...
Barten-Rijbroek, A.D. +7 more
core +6 more sources
ABSTRACT The aim of this study was to identify branches of the trigeminal and facial nerves (FNs) relevant to surgical incisions and injections and the scalp block techniques in the frontotemporal region, and to determine their relationships with superficial vascular structures and bony landmarks.
Hannah L. Grimes +5 more
wiley +1 more source
The heart of a dragon: 3D anatomical reconstruction of the ‘scaly-foot gastropod’ (Mollusca: Gastropoda: Neomphalina) reveals its extraordinary circulatory system [PDF]
Introduction The ‘scaly-foot gastropod’ (Chrysomallon squamiferum Chen et al., 2015) from deep-sea hydrothermal vent ecosystems of the Indian Ocean is an active mobile gastropod occurring in locally high densities, and it is distinctive for the dermal
Chen, Chong +4 more
core +2 more sources
Maximizing Neurovascular Outcomes of Facial Transplantation: A Comprehensive Review
ABSTRACT Facial transplantation is a division of reconstructive surgery which aims to improve the function and appearance of a face that has endured severe disfigurement. Currently, the face transplant procedure uses allogenic tissue, harvested from a brain‐dead donor, to replace damaged facial components.
Olivia A. James, Faye Bennett
wiley +1 more source
Posterior Auricle Bilobed Cartilage-skin Flap for Reconstructing the Earlobe: A Case Report
Summary:. Because the auricle plays an important role in facial aesthetics, all earlobe operations must seek to limit postoperative ear deformity.
Risa Nakazawa, MD +3 more
doaj +1 more source
Interventional therapies for chronic heart failure: An overview of recent developments
Abstract Heart failure (HF), the final manifestation of most cardiovascular diseases, has become a major global health concern, affecting millions of individuals. Despite basic drug treatments, patients present with high morbidity and mortality rates. However, recent advancements in interventional therapy have shown promising results in improving the ...
Bingchen Guo +7 more
wiley +1 more source

