Results 41 to 50 of about 128,048 (265)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

A translational regulator, PUM2, promotes both protein stability and kinase activity of Aurora-A. [PDF]

PLoS ONE, 2011
Aurora-A, a centrosomal serine-threonine kinase, orchestrates several key aspects of cell division. However, the regulatory pathways for the protein stability and kinase activity of Aurora-A are still not completely understood.
Yei-Hsuan Huang, Chun-Chi Wu, Chen-Kung Chou, Chi-Ying F Huang   +3 more
doaj   +1 more source

Agile collaboration: Citizen science as a transdisciplinary approach to heliophysics

Frontiers in Astronomy and Space Sciences, 2023
Citizen science connects scientists with the public to enable discovery, engaging broad audiences across the world. There are many attributes that make citizen science an asset to the field of heliophysics, including agile collaboration.
Vincent Ledvina, Vincent Ledvina, Laura Brandt, Laura Brandt, Elizabeth MacDonald, Elizabeth MacDonald, Nathaniel Frissell, Justin Anderson, Justin Anderson, Thomas Y. Chen, Ryan J. French, Francesca Di Mare, Francesca Di Mare, Andrea Grover, Karl Battams, Kristine Sigsbee, Bea Gallardo-Lacourt, Bea Gallardo-Lacourt, Donna Lach, Joseph A. Shaw, Michael Hunnekuhl, Burcu Kosar, Burcu Kosar, Wayne Barkhouse, Tim Young, Chandresh Kedhambadi, Dogacan S. Ozturk, Seth G. Claudepierre, Chuanfei Dong, Chuanfei Dong, Andy Witteman, Jeremy Kuzub, Jeremy Kuzub, Gunjan Sinha   +33 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Automatic detection method of polar cap arc based on YOLOX embedded with CBAM

Frontiers in Environmental Science
The aurora arc is a separate auroral structure from the aurora oval, whose location and morphology are related to various solar-terrestrial circumstances.
Yang Lu, Yang Lu, Jianan Jiang, Jia Zhong, Jia Zhong, Yong Wang, Yong Wang, Xiangyu Wang, Xiangyu Wang, Ziming Zou, Ziming Zou   +10 more
doaj   +1 more source

Reperfusion‐Dependent Outcomes After Endovascular Thrombectomy Stratified by NIHSS‐ASPECTS Clinical‐Core Mismatch

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This analysis evaluates the effect of successful reperfusion on functional outcomes after MT, stratified by admission National Institutes of Health Stroke Scale (NIHSS) and Alberta Stroke Program Early CT Score (ASPECTS) as surrogates for clinical‐core mismatch, using multicenter registry data.
Felix Schlicht, Lukas Meyer, Gabriel Broocks, Matthias Bechstein, Christian Thaler, Christian Heitkamp, Laurens Winkelmeier, Vincent Geest, Alexander Heitkamp, Maximilian Jungnitz, Gregor Peter, Luca Meucci, Tobias Faizy, Jawed Nawabi, Caspar Brekenfeld, Fabian Flottmann, Maximilian Schell, Alexandros Hadjilaou, Uta Hanning, Götz Thomalla, Jens Fiehler, Susanne Gellißen, Helge C. Kniep, for the German Stroke Registry Endovascular Treatment, (GSR‐ET) Alexander Nave, Anna Alegiani, Annerose Mengel, Arno Reich, Bernd Eckert, Charlotte Pietrock, Christian Nolte, Eberhard Siebert, Fabian Flottmann, Fee Keil, Franziska Dorn, Gabor Petzold, Götz Thomalla, Hanna Zimmermann, Jan Borggrefe, Jan Hendrik Schäfer, Jens Fiehler, Joachim Röther, Klaus Gröschel, Lars Kellert, Mario Abruscato, Maximilian Schell, Omid Nikoubashman, Peter Schellinger, Silke Wunderlich, Steffen Tiedt, Sven Thonke, Timo Uphaus, Tobias Boeckh‐Behrens, Ulrike Ernemann   +53 more
wiley   +1 more source

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source

Magnetic Storm‐Time Red Aurora as Seen From Hokkaido, Japan on 1 December 2023 Associated With High‐Density Solar Wind

Geophysical Research Letters
We report a citizen science‐motivated study on the cause of an unusually bright red aurora as witnessed from Hokkaido, Japan during a magnetic storm on 1 December 2023. The auroral brightness of 5 kR is unusual for the Dst index peak of only −107 nT.
Ryuho Kataoka, Yoshizumi Miyoshi, Kazuo Shiokawa, Nozomu Nishitani, Kunihiro Keika, Takanobu Amano, Kanako Seki   +6 more
doaj   +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro, Mackenzie Silverman, Maeve C. Lucas, Mariam M. Yousuf, Samuel T. Otey, Stella V. Gray, Brittany Jordan, Madeline D. Kahan, Latanya D. Agurs, Michelle Van Hirtum Das, Deborah Holder, Devin King, Eileen A. Quinn, Ryan Kammeyer, Michael S. Rafii   +14 more
wiley   +1 more source

pyGPI5: A python D- and E-region chemistry and ionization model

Frontiers in Astronomy and Space Sciences, 2022
We present a Python implementation of a D- and E-region chemistry and ionization code called pyGPI5. Particle precipitation that penetrates into the E- and D-region of the ionosphere-thermosphere causes significant enhancements of the electron density ...
Stephen R. Kaeppler, Robert Marshall, Ennio R. Sanchez, Diana H. Juarez Madera, Riley Troyer, Allison N. Jaynes   +5 more
doaj   +1 more source