Results 41 to 50 of about 1,081,054 (262)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Nurses, Foster Mothers, Businesswomen, and Baby‐Farmers: Market‐Based Infant Care in Pre‐WWI Australia

Social Inclusion
In 19th‐century Australia, there were few childcare options for mothers who needed to work. Residential institutions emerged as the colonial society’s preferred mode of placing older children, but they did not accommodate those below the age of two or ...
Nell Musgrove
doaj   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Comparative Comparison of the Curriculum of the Master\'s Degree in Emergency Nursing in Iran and Monash University in Australia [PDF]

Pizhūhish dar Āmūzish-i ̒ulūm-i Pizishkī
Introduction: Training emergency nurses plays a significant role in caring for critically ill patients. The comparison of emergency nursing curricula in Iran with those in prestigious universities is one of the ways to determine the strengths and ...
Mahdieh Motie, Narges Arsalani, Masoud Fallahi-Khoshknab   +2 more
doaj  

Rola Australii w polityce kryminalnej metropolii brytyjskiej na przełomie XVIII i XIX wieku

Acta Universitatis Lodziensis: Folia Historica, 2018
Artykuł opiera się na analizie kary zesłania. Autor porusza trzy główne kwestie. Po pierwsze, omówiono aktualny w tamtych czasach paradygmat kryminologii klasycznej.
Mateusz Nowak
doaj   +1 more source

Australia – Australia’s digital agenda [PDF]

Amicus Curiae, 2012
Article by Fiona Macmillan and Michael Blakeney of the Asia Pacific intellectual Property Law Institute, School of Law, Murdoch University, Western Australia examine reform to copyright law in Australia to take account of digital media and communications.
Macmillan, Fiona, Blakeney, Michael
openaire   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Drivers and barriers to innovation in the Australian public service: A qualitative thematic analysis

Engineering Management in Production and Services, 2019
The purpose of this paper was to identify common themes from archival records related to innovation in the Australian Public Service (APS). A thematic analysis was conducted to review and evaluate archival records which consisted of transcripts from ...
Wipulanusat Warit, Panuwatwanich Kriengsak, Stewart Rodney A., Sunkpho Jirapon   +3 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source