Results 121 to 130 of about 370,830 (302)

PROTAC‐Engineered Protein/DNA Nanoantigen is a Potent Booster for Dendritic Cell Vaccines in Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
A PROTAC‐functionalized protein/DNA‐integrated nanoantigen platform is developed to enhance dendritic cell vaccine potency. By combining a VHL‐recruiting peptide‐modified antigen with a sustained expression plasmid within CaCO3 nanoparticles, this system amplifies cross‐presentation, promotes DC maturation, and elicits robust Th1 and CTL responses ...
Peng Liu   +4 more
wiley   +1 more source

Inquiry-Based Knowledge Transformation: A Comparative Case of Two Secondary School Biology Teachers’ Involvement in an Extended Professional Learning Community Program

open access: yesEducation Sciences
This article presents a qualitative case study of two secondary school biology teachers who aligned their teaching to inquiry through an extended professional learning community (PLC) program. The case study used an inquiry-based knowledge mobility model
Joy Anogwih   +2 more
doaj   +1 more source

Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants

open access: yesAdvanced Science, EarlyView.
Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang   +14 more
wiley   +1 more source

High‐Power Hybrid Nanogenerator With Multi‐Degree‐of‐Freedom Mechanical Coupling for Harvesting Water Wave Energy

open access: yesAdvanced Science, EarlyView.
A high‐power hybrid nanogenerator (HP‐HNG) with multi‐degree‐of‐freedom mechanical coupling is reported, integrating multi‐directional wave energy for output to achieve 1 + 1 > 2 energy harvesting. The HP‐HNG achieves a peak output power of 0.764 W, corresponding to a peak power density of 127.303 W m−3. At a wave frequency of 1 Hz, the HP‐HNG delivers
Shuai Ding   +9 more
wiley   +1 more source

Insights into the nature and role of listening in the creation of a co-constructive coaching dialogue: A phenomenological study [PDF]

open access: yesInternational Journal of Evidence Based Coaching and Mentoring, 2016
Despite its importance, there seems to be no research into listening in coaching. Of the few texts that explore it, only Cox (2013) presents a theoretical foundation.
Peter Hill
doaj  

Mobile learning in higher education: Authentic tasks, assessment and Web 2.0 [PDF]

open access: yes, 2012
Increasingly ubiquitous and smart devices have enabled learning opportunities away from established learning places, as students have extended the means and the spaces in which they learn.
Herrington, J.   +2 more
core  

Deep Learning‐Driven Discovery and Engineering of an Efficient PETase for Depolymerization and Detoxification of PET Microplastics Under Physiological Conditions

open access: yesAdvanced Science, EarlyView.
A deep learning–driven pipeline mining 246 million protein sequences uncovers AhPETase, an evolutionarily distinct PET hydrolase. Engineered variant AhPETaseM1 degrades post‐consumer PET microplastics under physiological conditions and reverses microplasticinduced cytotoxicity in human lung and colon cells, establishing enzymatic microplastic ...
Yuxuan Wang   +9 more
wiley   +1 more source

Otantik Değerlendirme Yaklaşımlarının Ortaöğretim Öğrencilerinin Görsel Sanatlar Dersine Yönelik Tutumlarına Etkisi

open access: yesSelçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2014
Bu araştırmanın amacı, ortaöğretim görsel sanatlar dersinde uygulanan otantik değerlendirme yaklaşımlarının öğrencilerin derse yönelik tutum ve bu sürecin algılarıüzerindeki etkisini araştırmaktır.
Sehran Dilmaç, Oğuz Dilmaç
doaj  

The Authenticity Challenge in Digital and Social Media in Cultural Tourism: A Systematic Literature Review

open access: yesHeritage
Contemporary cultural tourism faces a critical digital authenticity paradox where social media engagement necessitates platform integration, yet algorithms prioritize engagement-driven content over culturally accurate heritage representations.
Nattapong Manlee, Kittichai Kasemsarn
doaj   +1 more source

Authentic mobile learning in higher education [PDF]

open access: yes, 2007
The ready availability and uptake of devices such as mobile phones, personal digital assistants and mobile music players, have permeated the manner and means of human communication, socializing and entertainment on a large scale.
Herrington, J., Herrington, A.
core  

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