Results 81 to 90 of about 588,972 (297)

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

open access: yesAdvanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang   +7 more
wiley   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

open access: yesAdvanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason   +12 more
wiley   +1 more source

THE EFFECTIVENESS OF USING AUTHENTIC MATERIALS ON TEACHING SPEAKING FOR ELEVENTH GRADE STUDENTS’ OF ISLAMIC HIGH SCHOOL STUDENTS OF MU’ALLIMIN MUHAMMADIYAH YOGYAKARTA IN ACADEMIC YEAR 2013/2014

open access: yesPaedagoria, 2018
The objectives of this research is to find out whether the using authentic materials on teaching speaking is effective for eleventh grade students of Islamic High School of  Mu’allimin Muhammadiyah Yogyakartain academic year 2013/2014 and whether there ...
Ilham Ilham
doaj   +1 more source

Legal Aid Work in Pennsylvania [PDF]

open access: yes, 1931
A primary goal of education is the acquisition of durable knowledge which challenges the use of efficient pedagogical methods of how to best facilitate learning.
Bradway, John S.
core   +1 more source

Place branding and the representation of people at work: Exploring issues of tourism imagery and migrant labour in the Republic of Ireland [PDF]

open access: yes, 2008
This paper addresses destination brand image in tourism marketing and assesses the contribution of tourism ' s workforce to such image and branding, considering the role that employees play in visitors ' interpretation of their experience of destination ...
Baum, T.G., Devine, F., Hearns, N.
core   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

open access: yesAdvanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao   +12 more
wiley   +1 more source

Pengaruh Metode Pembelajaran Authentic Material Terhadap hasil Belajar Bahasa Arab Siswa

open access: yesJurnal Educative, 2019
This study is quasi-experimental research which aims to determine the effect of authentic material on student learning outcomes on Arabic Language subjects at grade VIII MTsN 6 Agam.
Fajriyani Arsya, Loli Safitri
doaj   +1 more source

Decoding Naturalistic Episodic Memory with Artificial Intelligence and Brain‐Machine Interface

open access: yesAdvanced Science, EarlyView.
Episodic memory weaves together what, where, and when of experience into a personal narrative. Cutting‐edge AI models may decode this intricate process in real‐life settings, revealing how neural activity encodes naturalistic memories. By merging AI with brain–machine interfaces, researchers are edging closer to mapping and even engineering memory ...
Dong Song
wiley   +1 more source

THE USE OF AUTHENTIC MATERIAL TO IMPROVE STUDENTS’ READING COMPREHENSION

open access: yesEltin Journal, 2019
Teachers often have difficulties in finding the appropriate learning materials in teaching reading. Without appropriate reading texts that suit them, students spend long hours in the classroom with poor achievement in reading comprehension.
Pina Fitriana   +2 more
doaj   +1 more source

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

open access: yesAdvanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang   +21 more
wiley   +1 more source

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