Results 221 to 230 of about 420,085 (316)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

A lightweight zero-trust authentication architecture for IoT via unified enhanced FAST-SM9 and dynamic re-authentication. [PDF]

PLoS One
Ma Z, Wei H, Jiang J, Wang B, Wang H, Di Z.   +5 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Blockchain-Integrated Secure Authentication Framework for Smart Grid IoT Using Energy-Aware Consensus Mechanisms. [PDF]

Sensors (Basel)
Saleh OA, Cevik M.
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Blockchain-based secure MEC model for VANETs using hybrid networks. [PDF]

Sci Rep
Goud GV, Arunachalam R, Shukla SK, Saranya K, Venugopal S, Palanisamy P.   +5 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

PPG-based biometric authentication: A review on architectures, datasets, attacks and security challenges. [PDF]

Comput Struct Biotechnol J
Aguilar D, Martínez-Cruz A, Ramírez-Gutiérrez KA, Morales-Sandoval M.   +3 more
europepmc   +1 more source

Privacy-preserving Cosine Similarity Computation with Malicious Security Applied to Biometric Authentication

, 2023
Nan Cheng, Melek Önen, Aikaterini Mitrokotsa, Oubaïda Chouchane, Massimiliano Todisco, Alberto Ibarrondo   +5 more
openalex   +1 more source

Design an active verification mechanism for certificates revocation in OCSP for internet authentication

, 2020
Khalid F. Mahmmod, Mohammed M. Azeez, Zeyad Hashem Ismael   +2 more
openalex   +1 more source