Results 191 to 200 of about 258,419 (267)

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Two decades of agricultural drought impacts: remote sensing insights into vegetation productivity and phenological change in semi-arid Botswana. [PDF]

Environ Monit Assess
Akinyemi FO, Graw V.
europepmc   +1 more source

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

Psychometric Validation of the Arabic Version of the WPAI:Migraine Questionnaire in Patients with Migraine. [PDF]

Neurol Int
Albilali A, Almutawa RA, Almusahel EA, Almutawa RA, Almutawa NA, Almutawa FM, AlAujan S, AlMalag HM.   +7 more
europepmc   +1 more source

Microfluidic‐Driven Lipid Nanoparticles for Improved miRNA Delivery via Endo‐Lysosomal Trafficking Optimization

Advanced Science, EarlyView.
This study investigates the impact of various post‐processing methods (filtration, sonication, dialysis, and heating) on lipid nanoparticles produced using microfluidics. The nanoparticles are designed for efficient delivery of miRNA into cells. The work highlights how processing conditions influence nanoparticle stability and quality, providing ...
Alicja Kosik‐Kozioł, Michał Pruchniewski, Daniel Rybak, Piotr Jenczyk, Karolina Zakrzewska, Magdalena Bartolewska, Sławomir Błoński, Paweł Nakielski, Filippo Pierini   +8 more
wiley   +1 more source

Community-Level Phenotypic Adaptations of Small Mammals Under Rain-Shadow Dynamics in Baima Snow Mountain, Yunnan. [PDF]

Animals (Basel)
Li Y, Chen G, Xie M, Fang Y, Qin F, Song W.   +5 more
europepmc   +1 more source

Nutrient addition and herbivore exclusion alter plant traits and biomass via distinct mechanisms: intraspecific variability vs species turnover. [PDF]

New Phytol
Yan X, Virtanen R, Eskelinen A.
europepmc   +1 more source

[Production of 198Au grain (author's transl)].

Radioisotopes, 1977
A, Ando, M, Tadeshita, I, Ando, T, Hiraki, K, Hisada   +4 more
openaire   +1 more source