Results 251 to 260 of about 34,619 (289)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Defining the Boundaries of AI Use in Scientific Writing: A Comparative Review of Editorial Policies. [PDF]

J Korean Med Sci
Yoo JH.
europepmc   +1 more source

Artificial intelligence policies in bioethics and health humanities: a comparative analysis of publishers and journals. [PDF]

BMC Med Ethics
Bobier C, Rodger D, Hurst D.
europepmc   +1 more source

Supervisor's Positioning in Systemic Training: Complex Relational Space and Significant Oscillations. [PDF]

J Marital Fam Ther
Reséndiz Juárez G, Fruggeri L.
europepmc   +1 more source

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Authorial Stance and Identity Building in Weblogs by Law Scholars and Scientists

2023
This chapter examines comparatively how law and science bloggers construct their identity while communicating with their disciplinary community. Drawing on Hyland’s (Stance and engagement: A model of interaction in academic discourse. Discourse Studies, 7(2), 173–192, 2005a; Metadiscourse: Exploring interaction in writing. Bloomsbury (Continuum), 2005b)
Giuliana Diani, Maria Freddi
exaly   +4 more sources

DEVELOPMENT OF AUTHORIAL STANCE IN L2 ACADEMIC WRITING

INTED Proceedings, 2018
The paper addresses the issue of authorial stance development in L2 academic writing. One of the major challenges for ESP teachers is promoting academic communication proficiency among undergraduate and postgraduate students. Integration of young Russian scholars into international academic community presents a few challenges, efficient teaching of ...
M Rudneva, N Valeeva, Y Nigmatzyanova
exaly   +3 more sources