Results 91 to 100 of about 2,293,350 (305)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Increased system requirements and functional integration with the aircraft have placed an increased demand on control system capability and reliability.
Harkney, R. D.
core +1 more source
Automated Control of Subject Headings at the OSU Libraries [PDF]
, 1989 As more libraries acquire online catalogs, the interest and attention given to automated authority control continues to increase. Baer and Johnson recently did a survey of the authority control literature produced since 1974.
Rogers, Sally A.
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
The Optimal State Aid Control: No Control [PDF]
We extend a model of wasteful state aid in Dewatripont and Seabright (2006, Journal of the European Economic Association 4, 513–522) by a supranational controlling authority.
Dalibor Roháč, Martin Gregor
core +4 more sources
Incentives, Reputation and the Allocation of Authority [PDF]
We address the question how much authority a principal should delegate to a manager with conflicting interests and uncertain ability in a context in which the manager has both compensation-based and reputational incentives. The optimal level of authority
Ales Filipi +2 more
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Injury Epidemiology, 2019 Background This study examines social disparities across neighbourhood levels of income, education and employment in relation to overall injury hospital separations in the province of British Columbia, Canada.
Fahra Rajabali +7 more
doaj +1 more source
Simulator evaluation of the effects of reduced spoiler and thrust authority on a decoupled longitudinal control system during landings in wind shear [PDF]
The effect of reduced control authority, both in symmetric spoiler travel and thrust level, on the effectiveness of a decoupled longitudinal control system was examined during the approach and landing of the NASA terminal configured vehicle (TCV) aft ...
Miller, G. K., Jr.
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source