Results 171 to 180 of about 254,717 (266)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Assessment of compliance with good review practices by medicine assessors within the Zambia medicines regulatory authority. [PDF]
Chisha CS +4 more
europepmc +1 more source
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
A Blockchain-Enabled Multi-Authority Secure IoT Data-Sharing Scheme with Attribute-Based Searchable Encryption for Intelligent Systems. [PDF]
Zhang F, Xia X, Gao H, Ma Z, Chen X.
europepmc +1 more source
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Work conditions are associated with physical health in later life: a longitudinal cohort study in Taiwan. [PDF]
Cheng WJ +5 more
europepmc +1 more source
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Improving the communication of uncertainty in food safety on social media: a content analysis of aspartame risk messages. [PDF]
Chen Y, Luo S, Xu L, Tan M.
europepmc +1 more source

