Results 221 to 230 of about 11,126,758 (289)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Methodological Considerations in Interpreting Longitudinal Cognitive and Neural Changes Among Older Adults Who Continue Working. [PDF]

Psychogeriatrics
Naz A, Rayyan M, Saif H.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Methodological and Statistical Concerns Regarding "Nanofiber Matrix Dressing for Split-Thickness Skin Graft Donor Sites" [Letter]. [PDF]

Nanotechnol Sci Appl
He X.
europepmc   +1 more source

Correction: Codelivery of dihydroartemisinin and doxorubicin in mannosylated liposomes for drug-resistant colon cancer therapy. [PDF]

Acta Pharmacol Sin
Kang XJ, Wang HY, Peng HG, Chen BF, Zhang WY, Wu AH, Xu Q, Huang YZ.   +7 more
europepmc   +1 more source

Comments on "Re-Evaluation of the Ideal Injury to Flap Time Frame for Lower Extremity Free Flap Reconstruction: Is 72 h Still the Gold Standard?" [PDF]

Microsurgery
Aydin MS, Özler G, Kasap Ş, Nişancı M, Özvurmaz O.   +4 more
europepmc   +1 more source

Declining Self-Efficacy in Medical Students: Towards Empirical Testing of Adaptive Recalibration. [PDF]

Clin Teach
Sahin A, Vistari L, Lumbantoruan MLB, Saefudin DP, Rahman Z.   +4 more
europepmc   +1 more source

New article types at <i>BMJ Global Health</i>, and a statement on the use of artificial intelligence in global health research. [PDF]

BMJ Glob Health
Shrime MG.
europepmc   +1 more source

[Corrigendum] CLEC4M overexpression inhibits progression and is associated with a favorable prognosis in hepatocellular carcinoma. [PDF]

Mol Med Rep
Yu Q, Gao K.
europepmc   +1 more source

ERRATUM: Characterization of βlactoglobulin and κcasein genotypes PCR-RFLP in dairy cattle from Panama. [PDF]

Braz J Vet Med
europepmc   +1 more source