Results 71 to 80 of about 276,851 (299)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
On the Feasibility of Malware Authorship Attribution [PDF]
, 2016 There are many occasions in which the security community is interested to discover the authorship of malware binaries, either for digital forensics analysis of malware corpora or for thwarting live threats of malware invasion. Such a discovery of authorship might be possible due to stylistic features inherent to software codes written by human ...
Saed Alrabaee +3 more
openaire +2 more sources
Text Classification for Authorship Attribution Analysis [PDF]
Advanced Computing: An International Journal, 2013 10 ...
M. Sudheep Elayidom +3 more
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Significance of authorship in Patristic and Classical literature [PDF]
Вестник Православного Свято-Тихоновского гуманитарного университета: Серия I. Богословие, философия, 2012 The article is devoted to the study of various aspects of the problem of authorship of theological and literary works. It discusses causes of anonymity and pseudonimity, methods of identification and confirmation of authorship and the general ...
Nikolay Lipatov
doaj
Non-Traditional Authorship Attribution Studies of William Shakespeare’s Canon: Some Caveats
Journal of Early Modern Studies, 2016 The paper looks at the problems in conducting non-traditional authorship attribution studies on the canon of William Shakespeare. After a short introduction, the case is put forth that these studies are ‘scientific’ and must adhere to the tenets of the ...
Joseph Rudman
doaj +1 more source
Syntax Encoding with Application in Authorship Attribution [PDF]
Proceedings of the 2018 Conference on Empirical Methods in Natural Language Processing, 2018 We propose a novel strategy to encode the syntax parse tree of sentence into a learnable distributed representation. The proposed syntax encoding scheme is provably information-lossless. In specific, an embedding vector is constructed for each word in the sentence, encoding the path in the syntax tree corresponding to the word.
Richong Zhang +3 more
openaire +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source