Results 61 to 70 of about 585,856 (303)

Temporal and Cell‐Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1

Advanced Science, EarlyView.
Chd1, the Drosophila homologue of mammalian CHD2 ‐ a gene linked to autism, epilepsy, and intellectual disability, is required for synaptic homeostatic plasticity. Chd1 in glia is necessary for the rapid induction of synaptic homeostasis, whereas Chd1 in motoneurons, muscle, and glia is critical for long‐term maintenance.
Danielle T. Morency, Tao Cui, Yimei Cai, Chloe Lok, Rachel E. Nokku, Ruoxian Huang, Grace L. Chu, Yumeng Xie, Saleem W. Abu‐Tayeh, Kaikai He, Chengjie Qiu, Junyi Wang, Paxton M. Paganelli, Ting Wang, Gabrielle Williams, Sreejith Nair, Huadong Pei, Dion K. Dickman, Stefano Vicini, Tingting Wang   +19 more
wiley   +1 more source

A genome-first study of sex chromosome aneuploidies provides evidence of Y chromosome dosage effects on autism risk

Nature Communications
A female protective effect has long been postulated as the primary explanation for the four-fold increase of autism spectrum disorder (ASD) diagnoses in males versus females.
Alexander S. F. Berry, Brenda M. Finucane, Scott M. Myers, Lauren K. Walsh, John M. Seibert, Christa Lese Martin, David H. Ledbetter, Matthew T. Oetjens   +7 more
doaj   +1 more source

Cross-modal extinction in a boy with severely autistic behaviour and high verbal intelligence [PDF]

, 2008
Anecdotal reports from individuals with autism suggest a loss of awareness to stimuli from one modality in the presence of stimuli from another. Here we document such a case in a detailed study of T.M., a 13-year-old boy with autism in whom significant ...
Adini, Y, Akshoomoff, N, Belmonte, MK, Bonneh, YS, Houde, JF, Iversen, PE, Kenet, T, Merzenich, MM, Moore, CI, Pei, F, Simon, HJ   +10 more
core   +1 more source

Paving the Way to Elucidate Hg's Role in Tumorigenesis

Advanced Science, EarlyView.
Tumorigenesis can result from diverse environmental carcinogens. Among them, mercury—a lifelong bioaccumulative Group 2B carcinogen—has tumorigenic potential that remains poorly understood due to confounding co‐exposures and limited organ‐specific data.
Shouying Li, Rong Zhong, Zhenyang Yu, Hualing Fu, Jin Chen, Jia Wei, Ningwei Zhao, Le Qu, Tiantian Li, Wenli Tang, Huan Zhong   +10 more
wiley   +1 more source

From ivory tower to inclusion: Stakeholders’ experiences of community engagement in Australian autism research

Frontiers in Psychology, 2022
Autistic people, and other community stakeholders, are gaining increasing recognition as valuable contributors to autism research, resulting in a growing corpus of participatory autism research.
Jacquiline den Houting, Jacquiline den Houting, Julianne Higgins, Julianne Higgins, Kathy Isaacs, Kathy Isaacs, Joanne Mahony, Joanne Mahony, Elizabeth Pellicano, Elizabeth Pellicano, Elizabeth Pellicano   +10 more
doaj   +1 more source

A Review on the Cognitive Neuroscience of Autism [PDF]

, 2005
With increased recognition in the media, heightened prevalence, and advances in research technologies, investigation into the causes of autism has broadened in recent years.
Koyama, Alain
core  

Autism spectrum traits in normal individuals : a preliminary VBM analysis [PDF]

, 2015
In light of the new DSM-5 autism spectrum disorders diagnosis in which the autism spectrum reflects a group of neurodevelopmental disorders existing on a continuum from mild to severe expression of autistic traits, and recent empirical findings showing a
Focquaert, Farah, Vanneste, Sven
core   +3 more sources

High‐Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million‐Patient Diabetes Cohort

Advanced Science, EarlyView.
This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño, Víctor M. de la Oliva Roque, Javier‐Ignacio Ramirez‐Lopez, David P. Kreil, Joaquín Dopazo, Carlos Loucera   +5 more
wiley   +1 more source

Intellectual Development in Autism Spectrum Disorders: New Insights from Longitudinal Studies

Frontiers in Human Neuroscience, 2013
The presence/absence of Intellectual Disability (ID) is considered to be the most critical factor affecting outcomes in individuals with Autism Spectrum Disorders (ASD).
Giacomo eVivanti, Josephine eBarbaro, Kristelle eHudry, Cheryl eDissanayake, Margot ePrior   +4 more
doaj   +1 more source

Prospective and detailed behavioral phenotyping in DDX3X syndrome

Molecular Autism, 2021
Background DDX3X syndrome is a recently identified genetic disorder that accounts for 1–3% of cases of unexplained developmental delay and/or intellectual disability (ID) in females, and is associated with motor and language delays, and autism spectrum ...
Lara Tang, Tess Levy, Sylvia Guillory, Danielle Halpern, Jessica Zweifach, Ivy Giserman-Kiss, Jennifer H. Foss-Feig, Yitzchak Frank, Reymundo Lozano, Puneet Belani, Christina Layton, Bonnie Lerman, Emanuel Frowner, Michael S. Breen, Silvia De Rubeis, Ana Kostic, Alexander Kolevzon, Joseph D. Buxbaum, Paige M. Siper, Dorothy E. Grice   +19 more
doaj   +1 more source