Results 131 to 140 of about 3,152,180 (364)
Construction of pathogenic Sec16a mutation mouse model using CRISPR/Cas9
Animal Models and Experimental Medicine, EarlyView.Yaqiang Hu et al. engineered a pathogenic Sec16a mutant mouse model using CRISPR/Cas9 technology. They observed that the Sec16a mutant mice displayed diminished learning and memory capabilities, along with a limb‐clasping phenotype upon tail suspension.
Yaqiang Hu +6 more
wiley +1 more source
Annals of Neurology, EarlyView.Objective Antiseizure medication (ASM) use during pregnancy has increased over the past decade. However, evidence linking prenatal ASM exposure to neurodevelopmental disorders (NDDs) in offspring remains inconsistent. This study evaluated whether prenatal ASM exposure increases the risk of NDDs in children.
Odile Sheehy +13 more
wiley +1 more source
Harnessing the Neurobiology of Empathy and Compassion to Alleviate Burnout in Neurology
Annals of Neurology, EarlyView.The neurologist cares for patients with complex chronic conditions that compromise their wellbeing. Many such disorders are poorly understood. Whereas for some, effective symptomatic treatments exist, for most we lack an understanding of the molecular and cellular bases for disease pathogenesis needed for discovering disease‐modifying treatments ...
Fadel Zeidan +2 more
wiley +1 more source
Hydroxycarboxylic Acid Receptor 2 Mediates β‐hydroxybutyrate's Antiseizure Effect in Mice
Annals of Neurology, EarlyView.A Objective The ketogenic diet, a high‐fat, low‐carbohydrate regimen, is often used to treat drug‐resistant seizures and is being studied for Alzheimer's disease and other neuropsychiatric disorders. However, its mechanism of action remains unclear. β‐hydroxybutyrate, a primary circulating ketone body produced by the ketogenic diet, may mediate its ...
Soudabeh Naderi +10 more
wiley +1 more source
Autistic Spectrum Disorder: Behaviour Therapy, Relationship Therapy and Play; A Combined Future? [PDF]
, 2014 This review aims to look at the research undertaken in each of the two branches of Autistic Spectrum Disorder therapy, comparing and evaluating their individual successes and looking for an integrated way forward including the role of play and ...
MacDonald, Natalie
core
Autism Research, EarlyView.ABSTRACT Restricted and repetitive behaviors (RRB) are associated with sensory processing (SP) differences for autistic people, and are thought to be a coping strategy to help manage the sensory environment. Previous work shows that, for autistic people, alexithymia, intolerance of uncertainty (IU), and anxiety mediate the relationship between SP ...
Heather L. Moore +6 more
wiley +1 more source
Pediatric Health, Medicine and TherapeuticsDusabirema Immaculée,1 Girum Sebsibie Teshome,2 Dieudonne Kayiranga,2 Philomene Uwimana2 1Department of Operation Room, Rwamagana Level II Teaching Hospital, Rwamagana, Rwanda; 2School of Nursing and Midwifery, College of Medicine and Health Sciences ...
Immaculée D +3 more
doaj
Autism Research, EarlyView.ABSTRACT Prominent theories of autism suggest autism‐associated differences in visual‐motor integration (VMI) may disrupt learning of motor and social skills typically acquired by observation and imitation. Supporting these theories, children with autism spectrum disorder (ASD) show robust differences in motor tasks reliant on dynamic VMI (e.g., ball ...
Jonah McLaughlin +3 more
wiley +1 more source
The specific brain imaging alteration underlying the autistic traits in children with attention-deficit/hyperactivity disorder [PDF]
, 2023 Juan Liu +14 more
openalex +1 more source