Results 61 to 70 of about 1,859,984 (354)

The DEC2‐SCN2A Axis is Essential for the Anticonvulsant Effects of Cannabidiol by Modulating Neuronal Plasticity

Advanced Science, EarlyView.
This study identifies DEC2 as a critical transcriptional repressor of Scn2a that directly binds E‐box motifs in its promoter to regulate neuronal plasticity and epileptogenesis. Functional manipulation of DEC2 alters seizure susceptibility in vivo. Cannabidiol enhances this repression, unveiling a novel DEC2‐SCN2A axis underlying its anticonvulsant ...
Huifang Song, Yifan Wang, Lili Wang, Chang Guo, Shiqi Liu, Yi Rong, Jiawen Tian, Chao Peng, Yuying Shao, Zhixiong Ma, Na Li, Jingliang Zhang, Zijun Peng, Xu Yan, Hangwei Fa, Xinyue Ma, Jie Dong, Jinping Ji, Chen Yang, Haocheng Chen, Jing Liang, Qi Sun, Yang Yang, Weining Ma, Zhuo Huang   +24 more
wiley   +1 more source

Presence and correlates of autistic traits among patients with social anxiety disorder

Frontiers in Psychiatry
IntroductionDue to their similar behavioral presentation, it can sometimes be challenging to distinguish between a social anxiety disorder (SAD) and the social avoidance that is frequently described in autism spectrum disorder (ASD).
Barbara Carpita, Benedetta Nardi, Chiara Bonelli, Enrico Massimetti, Giulia Amatori, Ivan Mirko Cremone, Stefano Pini, Liliana Dell’Osso   +7 more
doaj   +1 more source

Do We Need Autistic Autism Researchers to Understand Autism?

Ethics in Progress, 2023
The assumption that autistic individuals do not have the theory of mind – the social-cognitive ability to understand other people by attributing mental states to them – has been widespread in the psychological literature. However, the empirical evidence
Agnieszka Kędra
doaj   +1 more source

Autism and Communication: A Phenomenology of Parents’ Perspectives [PDF]

, 2018
Autism spectrum disorders (ASD) are characterized by language impairments and are often treated with a variety of communication interventions. In addition to these interventions, the parents of autistic children have to learn how to care for and ...
Sargent, Zoe
core   +1 more source

Parents' future visions for their autistic transition-age youth: hopes and expectations [PDF]

, 2018
Researchers have documented that young adults with autism spectrum disorder have poor outcomes in employment, post-secondary education, social participation, independent living, and community participation. There is a need to further explore contributing
Chen, Jennifer, Cohn, Ellen S., Orsmond, Gael I.   +2 more
core   +1 more source

Inhibition of Phosphodiesterase 10A by MP‐10 Rescues Behavioral Deficits and Normalizes Microglial Morphology and Synaptic Pruning in A Mouse Model of FOXP1 Syndrome

Advanced Science, EarlyView.
We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich, Jing Wang, Ferdinand Althammer, Tim Schubert, Nina Kluck, Valery Grinevich, Stefanie Schmitteckert, Christian P. Schaaf, Gudrun A. Rappold   +8 more
wiley   +1 more source

Schedules for the detection, diagnosis, and assessment of autistic spectrum disorder [PDF]

, 2001

  +8 more sources

Auditory Processing Differences Correlate With Autistic Traits in Males

Frontiers in Human Neuroscience, 2020
Autism spectrum disorder (ASD) has high prevalence among males compared to females but mechanisms underlying the differences between sexes are poorly investigated.
Simge Aykan, Emre Gürses, Suna Tokgöz-Yılmaz, Suna Tokgöz-Yılmaz, Canan Kalaycıoğlu   +4 more
doaj   +1 more source

The association between autistic traits and quality of social interactions in the daily life of adolescents and young adults

European Psychiatry, 2023
Introduction Autism spectrum disorder (ASD) is a heterogenous groups of neurodevelopmental conditions characterized by difficulties in social communication and the presence of restricted interests and repetitive behaviors.
L. Fusar-Poli, T. Investigators, J. van Os, B. P. Rutten, S. Guloksuz   +4 more
doaj   +1 more source

Attitudes Toward Autism [PDF]

, 2009
Many studies have been conducted to observe the effect of contact on attitudes toward people with mental illnesses, but few studies have observed the effect of contact on attitudes toward individuals on the autism spectrum specifically.
Edyvean, Carrie
core   +2 more sources