Results 71 to 80 of about 156,470 (344)

Genetic Diagnosis and Discovery Enabled by Large Language Models

Advanced Science, EarlyView.
We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu, Khaled Saab, Weida Liu, Zhouqing Fang, Zhuanfen Cheng, Svetolik Spasic, Maja Djurisic, Hiroaki Mohri, Wenlong Ren, Anil Palepu, Juraj Gottweis, Alan Karthikesalingam, Kavita Kulkarni, Annalisa Pawlosky, Devon Bonner, Elijah Kravets, Shruti Marwaha, Hector R. Mendez, Matthew T. Wheeler, Jonathan A. Bernstein, Undiagnosed Diseases Network, Cheng‐Yu Tsai, Chen‐Chi Wu, Konstantina M. Stankovic, Vivek Natarajan, Gary Peltz   +25 more
wiley   +1 more source

The Melatonin Receptor Agonist Ramelteon Effectively Treats Insomnia and Behavioral Symptoms in Autistic Disorder

Case Reports in Psychiatry, 2014
Children with autism spectrum disorders (ASD), including autistic disorder, frequently suffer from comorbid sleep problems. An altered melatonin rhythm is considered to underlie the impairment in sleep onset and maintenance in ASD.
Kentaro Kawabe, Fumie Horiuchi, Yasunori Oka, Shu-ichi Ueno   +3 more
doaj   +1 more source

Do Alternative Therapies Have a Role in Autism? [PDF]

, 2010
Interventions considered to be branches of Complementary & Alternative Medicine (CAM) for autism are on the rise. Many new treatments have emerged & traditional beliefs of Ayurveda, Yoga, Behavioral therapy, Speech therapy and Homoeopathy have gained ...
Ghosh, S, Koch, M, Rao, AN, Suresh Kumar, V   +3 more
core   +1 more source

Faces do not capture special attention in children with autism spectrum disorder: a change blindness study [PDF]

, 2009
Two experiments investigated attention of children with autism spectrum disorder (ASD) to faces and objects. In both experiments, children (7- to 15-year-olds) detected the difference between 2 visual scenes.
Adolphs, American Psychiatric Association, Aylward, Baron-Cohen, Bird, Critchley, Dalton, Dawson, Dawson, Farroni, Fletcher-Watson, Grelotti, Hadjikhani, Hadjikhani, Happé, Haxby, Hobson, Howard, Hubl, Humphreys, Japanese WISC-III Publication Committee, Johnson, Johnson, Joseph, Kemper, Klin, Klin, Langton, Levin, Maestro, Mars, Matsumoto, Morton, Osterling, Osterling, O’Regan, Palermo, Pierce, Piggot, Raven, Rensink, Rensink, Ro, Ro, Scholl, Schultz, Schultz, Schumann, Shah, Shore, Sigman, Simons, Simons, Simons, Sparks, Speer, Spezio, Sugishita, Swettenham, van der Geest, Vuilleumier, Wang, Wechsler, Werner, Wimpory, Wojciulik, Yokosawa   +66 more
core   +1 more source

Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling

Advanced Science, EarlyView.
Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu, Zhi‐Bin Hu, Ling Hu, Yu‐Bing Wang, Qiong Zhang, Ning‐Ning Song, Xi‐Yue Liu, Jia‐Yin Chen, Hong‐Wen Zhu, Bing‐Yao Zhou, Yun‐Chao Tao, Li Zhao, Ze‐Xuan Li, Yi‐Wei Li, Jia‐Qi Chen, Si‐Xin Tu, Cong‐Cong Qi, Sai‐Dan Ding, Gang Peng, Lin Xu, Yu‐Qiang Ding   +20 more
wiley   +1 more source

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long‐Term Active Place Avoidance Memory and “Shadow” Proteins

Advanced Science, EarlyView.
Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han, Alejandro Grau‐Perales, Rayna M. Harris, Edith Lesburguères, Hsin‐Yi Kao, Asit Pal, Juan Marcos Alarcon, Todd C. Sacktor, Stefano Martiniani, Hans A. Hofmann, André A. Fenton   +10 more
wiley   +1 more source

Memory, learning and language in autism spectrum disorder [PDF]

, 2018
Background and aims: The ‘dual-systems’ model of language acquisition has been used by Ullman and colleagues to explain patterns of strength and weakness in the language of higher-functioning people with autism spectrum disorder (ASD).
Bodison S., Boucher J., Bowler D., Fay W., Kim S. H., Mottron L., Prévost P., Tager-Flusberg H., Travers B. G., Wing L.   +9 more
core   +2 more sources

Memory in autism spectrum disorder: a meta-analysis of experimental studies [PDF]

, 2020
To address inconsistencies in the literature on memory in Autism Spectrum Disorder (ASD), we report the first ever meta-analysis of short-term (STM) and episodic long-term (LTM) memory in ASD, evaluating the effects of type of material, type of retrieval
Baylete, J-M., Bowler, D. M., Briant, A. R., Desaunay, P., Eustache, F., Gerardin, P., Guénolé, F., Parienti, J-J., Ring, M.   +8 more
core   +1 more source

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
wiley   +1 more source

Effects of Equine Assisted Therapy on Response Reaction Time and Attention Span of Youthswith Autistic Spectrum Disorder

International Journal of Child Development and Mental Health, 2016
The objectives of this research were to develop and investigate the effect of equine assisted therapy on the reaction time and attention span of youths with autistic spectrum disorder (ASD). This research was a quasi – experimental design.
Supattikorn Yotchukiat, Maethisa Pongsaksri, Siriporn Peansu   +2 more
doaj