Results 171 to 180 of about 34,284 (266)

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Brain Lesion Synthesis via Progressive Adversarial Variational Auto-Encoder. [PDF]

Simul Synth Med Imaging, 2022
Huo J, Vakharia V, Wu C, Sharan A, Ko A, Ourselin S, Sparks R.   +6 more
europepmc   +1 more source

POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation

Advanced Science, EarlyView.
Schematic diagram of our study showing that highly expressed POU2F1 in colorectal cancer (CRC) can directly accelerate the cytosolic lactate export to decrease PPP1R11 lactylation at K59, thereby attenuating the E3 ligase enzyme activity and protein stability of PPP1R11, which inhibits the ubiquitination of MDR2 at K413 and K538 but increases the ...
Longzheng Xia, Jinguan Lin, Xianjie Jiang, Linda Oyang, Shiming Tan, Zongyao Ren, Qiu Peng, Qianjin Liao, Yujuan Zhou   +8 more
wiley   +1 more source

Conditional variational auto encoder based dynamic motion for multitask imitation learning. [PDF]

Sci Rep
Xu B, Ud Din M, Hussain I.
europepmc   +1 more source

A deep learning approach for morphological feature extraction based on variational auto-encoder: an application to mandible shape. [PDF]

NPJ Syst Biol Appl, 2023
Tsutsumi M, Saito N, Koyabu D, Furusawa C.   +3 more
europepmc   +1 more source

Cars2‐Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2

Advanced Science, EarlyView.
We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng, Hongyong Song, Yin Long, Kaimin Wu, Yinkun Fu, Wenkai Zhou, Wenyan Li, Zhe Shi, Xu‐Yun Zhao   +8 more
wiley   +1 more source

Correction: Visual impairment prevention by early detection of diabetic retinopathy based on stacked auto-encoder. [PDF]

Sci Rep
Almas S, Wahid F, Ali S, Alkhyyat A, Ullah K, Khan J, Lee Y.   +6 more
europepmc   +1 more source

Smart Optogenetics for Real‐Time Automated Control of Cardiac Electrical Activity

Advanced Science, EarlyView.
We are able to stop dangerous heart‐rhythm spirals before they fully form. Within about 100 ms, it pinpoints the spiral's tiny central tip (≈0.9 mm) using light‐based sensing and machine learning, then shines targeted light to shut it down. This fast, precise, closed‐loop approach detects, targets, and terminates arrhythmias in real time.
Shanliang Deng, Niels Harlaar, Juan Zhang, Sven O. Dekker, Nina N. Kudryashova, Huiling Zhou, Cindy I. Bart, TianYi Jin, Georgy Derevyanko, Willem van Driel, Alexander V. Panfilov, René H. Poelma, Antoine A. F. de Vries, GuoQi Zhang, Tim De Coster, Daniël A. Pijnappels   +15 more
wiley   +1 more source

BHFVAL: Block chain-Enabled Hierarchical Federated Variational Auto encoder Framework for Secure Intrusion Detection in Vehicular Networks. [PDF]

Sci Rep
Visuvanathan GE, Sayeed MS, Yogarayan S.
europepmc   +1 more source

RETRACTED ARTICLE: Utilizing variable auto encoder-based TDO optimization algorithm for predicting loneliness from electrocardiogram signals. [PDF]

Soft comput, 2023
Bharathi Vidhya R, Jerritta S.
europepmc   +1 more source