Results 141 to 150 of about 39,760 (245)

Adaptive model predictive control scheme for partially internal thermally coupled air separation column

Results in Engineering
Partially Internal Thermally Coupled Air Separation Column (P-ITCASC) is a highly energy-efficient and cost-effective technology. However, its complex dynamics resulting from thermal coupling pose a challenge to the operating stability of this technology.
Hamedalneel Babiker Aboh Hamid, Xinggao Liu   +1 more
doaj   +1 more source

Generating Sketches in a Hierarchical Auto-Regressive Process for Flexible Sketch Drawing Manipulation at Stroke-Level

Proceedings of the AAAI Conference on Artificial Intelligence
Generating sketches with specific patterns as expected, i.e., manipulating sketches in a controllable way, is a popular task. Recent studies control sketch features at stroke-level by editing values of stroke embeddings as conditions. However, in order to provide generator a global view about what a sketch is going to be drawn, all these edited ...
Sicong Zang, Shuhui Gao, Zhijun Fang 0001   +2 more
openaire   +2 more sources

Diffusion‐Based Generative Model With Scaffold‐Hopping Strategy Yields Highly Potent Bioactive Molecules

Advanced Science, EarlyView.
SMarT‐Diff introduces a multi‐objective generative paradigm that integrates scaffold hopping with structure‐aware scoring to enable controlled exploration beyond the training distribution. The framework consistently balances drug‐likeness, synthesizes accessibility and bioactivity, yielding chemically diverse candidates with enhanced properties.
Yuwei Yang, Xiaoqing Gong, Shukai Gu, Jing Li, Bo Liu, Yanan Tian, Qianqian Zhang, Xiaojun Yao, Huanxiang Liu   +8 more
wiley   +1 more source

Negative binomial integer-valued auto-regressive process for longitudinal count data

Journal of Statistical Research
This paper proposes a longitudinal integer-valued auto-regressive model of order one with Negative-Binomial marginals. The proposed model is suitable for analyzing repeated count data that exhibits significant over-dispersion at each time point and that is exposed to sev- eral time-dependent covariates.
NAUSHAD MAMODE KHAN, VANDNA JOWAHEER, YUVRAJ SUNECHER   +2 more
openaire   +1 more source

PlantGFM: A Genomic Foundation Model for Discovery and Creation of Plant Genes

Advanced Science, EarlyView.
A plant genomic foundation model pre‐trained on 12 species enables both accurate gene prediction and de novo gene design. Through AI‐human knowledge screening, seven designed sequences showed transcriptional activity in plants, with two expressing stable proteins—demonstrating the first DNA‐RNA‐protein expression of LLM‐generated genes in plants and ...
Changhao Li, Qizhe Zhang, Hanchen Chen, Kepeng Lin, Chengfang Luo, Mengying Yang, Wei Xu, Fan Yao, Jianbing Yan, Qing‐Yong Yang, Xuehai Hu   +10 more
wiley   +1 more source

Business Cycle and Risk Premium in the Colombian Stock Market

Ecos de Economía, 2013
Through the Hodrick-Prescott methodology this paper presents a review about the relationship between the ex post risk premium of the stock market and business cycles observed in Colombia.
Andrés Mauricio Gómez Sánchez, José Gabriel Astaiza Gómez   +1 more
doaj  

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Intramolecular Interactions between Folded and Disordered Regions Shape Ubiquilin Structure and Function

Advanced Science, EarlyView.
Ubiquilin (UBQLN), like many other human proteins, contains both well‐folded and disordered regions. Here, we show that intramolecular interactions between disordered regions and folded domains modulate between open and closed topologies of UBQLN proteins, altering their structure and function.
Jessica K. Niblo, Nirbhik Acharya, Maxwell B. Watkins, Carlos A. Castañeda, Shahar Sukenik   +4 more
wiley   +1 more source

Sociological Lives and Auto/Biographical Writing

, 2002
This article arises from some reflections on the role of the researcher in the context of writing an account of my educational experience (Roberts, 1998) and the realisation that I had written various accounts of my educational (university) experience
Roberts, Brian
core  

Advances in Cancer Immunotherapy for Solid Tumors

Advanced Science, EarlyView.
Cancer immunotherapy for solid tumors is rapidly evolving beyond classical checkpoint blockade toward more precise strategies. Emerging checkpoint targets, bispecific antibodies, antibody–drug conjugate combinations, personalized vaccines, cellular therapies, and engineered cytokines are expanding therapeutic possibilities, while biomarker‐guided ...
Shira Gabizon‐Peretz, Harriet M. Kluger   +1 more
wiley   +1 more source