Results 181 to 190 of about 8,251,079 (331)

Universal Gripper for Industrial Manipulation With Enhanced Rigid Mechanics and Self‐Adaptable Fingers

Advanced Robotics Research, EarlyView.
An enhanced universal gripper combining rigid mechanics with self‐adaptable fingers is presented for industrial automation. The novel six‐bar linkage with integrated compliant pad eliminates mechanical interference while enabling passive shape adaptation.
Muhammad Usman Khalid, Nirmal Kumar Ravikumar, Mattia Frascio, Sumanth Nagalakunta, Alessandro Seitone, Benoît Lévesque, Alessandro Zanella, Matteo Zoppi   +7 more
wiley   +1 more source

Navigating polymorph generation and distilled-potential development via entropy-symmetry landscapes for metal plasticity mechanisms. [PDF]

Nat Commun
Li Z, Liu T, Wan X, Zhao S, Zhang Z, Zhou E, Yu W, Zuo Y, Robertson J, Liu S, Guo Y.   +10 more
europepmc   +1 more source

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

A benchmark of semi-supervised scRNA-seq integration methods in real-world scenarios. [PDF]

PLoS Comput Biol
Shen X, He C, Guan L.
europepmc   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Olympiad-level formal mathematical reasoning with reinforcement learning. [PDF]

Nature
Hubert T, Mehta R, Sartran L, Horváth MZ, Žužić G, Wieser E, Huang A, Schrittwieser J, Schroecker Y, Masoom H, Bertolli O, Zahavy T, Mandhane A, Yung J, Beloshapka I, Ibarz B, Veeriah V, Yu L, Nash O, Lezeau P, Mercuri S, Sönne C, Mehta B, Davies A, Zheng D, Pedregosa F, Li Y, von Glehn I, Rowland M, Albanie S, Velingker A, Schmitt S, Lockhart E, Hughes E, Michalewski H, Sonnerat N, Hassabis D, Kohli P, Silver D.   +38 more
europepmc   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Conditional organs-of-interest segmentation with plausible inter-fraction variation simulation for pancreatic magnetic resonance-guided radiotherapy in limited-data settings. [PDF]

Phys Imaging Radiat Oncol
Shojaei M, Eiben B, McClelland JR, Nill S, Dunlop A, Chuter RW, Hunt A, Ng-Cheng-Hin B, Oelfke U.   +8 more
europepmc   +1 more source

Cloud Auto-scaling Auditing Approach using Blockchain

Auto-scaling mechanisms are frequently activated when deploying applications in the cloud environment. They are vital to ensure the application is capable of maintaining the requisite Quality of Service.
Bergami G, Al-Sharidah AA, Barati M, Ranjan R   +3 more
core  

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source