Results 301 to 310 of about 251,978 (341)
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Rheumatic Disease Clinics of North America, 1988
The diagnosis of SLE is associated with an enlarging assortment of autoantibodies. The presence or absence of particular antibodies influences the confidence with which this diagnosis is made. It is the presence of autoantibodies and the deposit of immunoglobulin that has led to the general conclusion that lupus is an autoimmune disease.
J B, Harley, K K, Gaither
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The diagnosis of SLE is associated with an enlarging assortment of autoantibodies. The presence or absence of particular antibodies influences the confidence with which this diagnosis is made. It is the presence of autoantibodies and the deposit of immunoglobulin that has led to the general conclusion that lupus is an autoimmune disease.
J B, Harley, K K, Gaither
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Archives of Dermatology, 1976
To the Editor.— The association of vitiligo with a number of organspecific autoimmune disorders, such as pernicious anemia, 1 hyperthyroidism and hypothyroidism, 2 Addison disease, 3 and diabetes mellitus 4 is well known. An increased incidence of organ-specific antibodies was reported in patients with vitiligo, 5,6 but, more recently, no ...
BETTERLE, CORRADO +6 more
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To the Editor.— The association of vitiligo with a number of organspecific autoimmune disorders, such as pernicious anemia, 1 hyperthyroidism and hypothyroidism, 2 Addison disease, 3 and diabetes mellitus 4 is well known. An increased incidence of organ-specific antibodies was reported in patients with vitiligo, 5,6 but, more recently, no ...
BETTERLE, CORRADO +6 more
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Current Opinion in Immunology, 1995
Autoantibodies of the IgM, IgG and IgA classes, reactive with a variety of serum proteins, cell surface structures and intracellular structures, are 'naturally' found in all normal individuals. Present in human cord blood and in 'antigen-free' mice, their variable-region repertoire is selected by antigenic structures in the body and remains conserved ...
A, Coutinho +2 more
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Autoantibodies of the IgM, IgG and IgA classes, reactive with a variety of serum proteins, cell surface structures and intracellular structures, are 'naturally' found in all normal individuals. Present in human cord blood and in 'antigen-free' mice, their variable-region repertoire is selected by antigenic structures in the body and remains conserved ...
A, Coutinho +2 more
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Nature Reviews Rheumatology, 2018
The discovery of novel autoantigen systems related to idiopathic inflammatory myopathies (collectively referred to as myositis) in adults and children has had major implications for the diagnosis and management of this group of diseases across a wide range of medical specialties.
Neil J, McHugh, Sarah L, Tansley
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The discovery of novel autoantigen systems related to idiopathic inflammatory myopathies (collectively referred to as myositis) in adults and children has had major implications for the diagnosis and management of this group of diseases across a wide range of medical specialties.
Neil J, McHugh, Sarah L, Tansley
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Autoantibodies to Ribonucleoproteins
Clinics in Rheumatic Diseases, 1985Presently we recognize at least 12 different autoantibodies that involve ribonucleoproteins as antigens in patients with SLE and other rheumatic diseases. Such autoantibodies have a number of clinically useful diagnostic associations. Moreover, they have proved to be powerful tools for understanding the structure and function of a variety of cellular ...
J A, Hardin, T, Mimori
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Epilepsia, 2011
SummaryIn a substantial number of patients with epilepsy, the etiology of the seizure disorder remains unknown. In recent years, the detection of autoantibodies has contributed to the etiologic understanding of a substantial number of so far unexplained epilepsies.
Christian G, Bien, Ingrid E, Scheffer
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SummaryIn a substantial number of patients with epilepsy, the etiology of the seizure disorder remains unknown. In recent years, the detection of autoantibodies has contributed to the etiologic understanding of a substantial number of so far unexplained epilepsies.
Christian G, Bien, Ingrid E, Scheffer
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Autoantibodies and their significance
Current Opinion in Rheumatology, 1993In systemic lupus erythematosus, autoantibodies have structural features that indicate in vivo selection by a T cell-dependent, antigen-driven process. The B-cell component of these responses resembles a conventional antibody response, whereas the T-cell component may involve diverse stimulatory mechanisms and levels of regulatory control ...
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Rheumatic Disease Clinics of North America, 1992
The antinuclear and antinucleolar antibodies found in patients with scleroderma are discussed. Many of the autoantigens have been characterized, the cDNA cloned and the epitopes defined. Many of the more common autoantigens are DNA-binding proteins, which are very important in transcription and in cell division.
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The antinuclear and antinucleolar antibodies found in patients with scleroderma are discussed. Many of the autoantigens have been characterized, the cDNA cloned and the epitopes defined. Many of the more common autoantigens are DNA-binding proteins, which are very important in transcription and in cell division.
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Diabetes, 2005
Islet cell autoantibodies are strongly associated with the development of type 1 diabetes. The appearance of autoantibodies to one or several of the autoantigens—GAD65, IA-2, or insulin—signals an autoimmune pathogenesis of β-cell killing. A β-cell attack may be best reflected by the emergence of autoantibodies dependent on the genotype risk factors ...
Catherine, Pihoker +3 more
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Islet cell autoantibodies are strongly associated with the development of type 1 diabetes. The appearance of autoantibodies to one or several of the autoantigens—GAD65, IA-2, or insulin—signals an autoimmune pathogenesis of β-cell killing. A β-cell attack may be best reflected by the emergence of autoantibodies dependent on the genotype risk factors ...
Catherine, Pihoker +3 more
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Current Diabetes Reports, 2016
Islet autoantibodies are the main markers of pancreatic autoimmunity in type 1 diabetes (T1D). Islet autoantibodies recognize insulin (IAA), glutamic acid decarboxylase (GADA), protein phosphatase-like IA-2 (IA-2A), and ZnT8 (ZnT8A), all antigens that are found on secretory granules within pancreatic beta cells.
Vito, Lampasona, Daniela, Liberati
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Islet autoantibodies are the main markers of pancreatic autoimmunity in type 1 diabetes (T1D). Islet autoantibodies recognize insulin (IAA), glutamic acid decarboxylase (GADA), protein phosphatase-like IA-2 (IA-2A), and ZnT8 (ZnT8A), all antigens that are found on secretory granules within pancreatic beta cells.
Vito, Lampasona, Daniela, Liberati
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