Results 271 to 280 of about 137,333 (337)

Clinical Characteristics and Risk Factors for Cutaneous Manifestations Associated With Nemolizumab in Atopic Dermatitis: A Multicenter Retrospective Study in Japan

The Journal of Dermatology, EarlyView.
ABSTRACT Nemolizumab, an anti‐interleukin‐31 receptor A monoclonal antibody, has been approved in Japan for treating atopic dermatitis (AD)‐associated pruritus. While it is effective for itch control, nemolizumab‐associated cutaneous adverse events have been increasingly recognized, yet their clinical features remain poorly characterized. In this study,
Wataru Sasaki, Ryo Saito, Kenta Suzuki, Daisuke Watanabe, Masako Minami‐Hori, Hirofumi Kamada, Hiroo Amano, Akihiko Uchiyama, Sei‐ichiro Motegi, Machiko Kamura, Kazunari Sugita, Noriko Kubota, Toshifumi Nomura, Maki Ozawa, Toshiya Takahashi, Takashi Yamakita, Kazumitsu Sugiura, Tetsuharu Ikegami, Ken Igawa, Yuka Kimura, Yoko Kataoka, Ryoichi Kamide, Masakazu Takahashi, Akio Tanaka, Mariko Sugawara‐Mikami   +24 more
wiley   +1 more source

Retraction: Relationship between the Autoantibody and Expression of β3-Adrenoceptor in Lung and Heart. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

Circadian Gene BMAL1 Regulation of Cellular Senescence in Thyroid Aging

Aging Cell, EarlyView.
BMAL1 downregulation during aging reduces NFKBIA expression, accelerating thyroid cellular senescence and impairing hormone synthesis. Circadian rhythm disruption exacerbates thyroid functional decline, highlighting the BMAL1‐NFKBIA axis as a key mediator of aging‐related thyroid dysfunction and offering insights for stabilizing thyroid health in aging
Dandan Zong, Baihui Sun, Qiting Ye, Hongxin Cao, Haixia Guan   +4 more
wiley   +1 more source

A case-control study on the role of carbonic anhydrase autoantibodies in the pathogenesis and diagnosis of fibromyalgia. [PDF]

Sci Rep
Kılıç H, Hasanova N, Topaloğlu MS, Şahin E, Sağlam N, Alemdar NT, Menteşe A.   +6 more
europepmc   +1 more source

Non‐Allergic Urticarial Skin Reactions Associated With MOv18 IgE, a First‐In‐Class IgE Antibody Recognising Folate Receptor Alpha

Allergy, EarlyView.
MOv18 IgE, the first‐in‐class IgE antibody targeting the cancer antigen folate receptor alpha (FR⍺) showed early signs of efficacy and was well tolerated in a first‐in‐human clinical trial, with transient urticarial skin reactions as the most common toxicity.
Chara Stavraka, Jitesh Chauhan, Silvia Crescioli, Sheila M. McSweeney, Amy Pope, Cheryl Gillett, Ashley Di Meo, Ioannis Prassas, Roman Laddach, Katie Stoker, Alexandra J. McCraw, Rebecca Adams, Thomas J. Tull, Nabeel Naban, Zena Willsmore, Kristina V. Semkova, Clive E. H. Grattan, John McGrath, Stephen J. Till, Christopher J. Corrigan, Rebecca Kristeleit, Sophia Tsoka, Eleftherios P. Diamandis, Katie E. Lacy, Sarah Pinder, Debra H. Josephs, James Spicer, Heather J. Bax, Sophia N. Karagiannis   +28 more
wiley   +1 more source

Anti-Sp4 and anti-CCAR1 autoantibodies in UK vs US patients with adult and juvenile-onset anti-TIF1γ-positive myositis. [PDF]

Rheumatology (Oxford)
McMorrow FK, Wedderburn LR, Chinoy H, Oldroyd A, Lamb JA, Rider LG, Mammen AL, Casciola-Rosen L, McHugh NJ, Tansley SL, UK JDCBS and Childhood Myositis Heterogeneity Study Group .   +10 more
europepmc   +1 more source

The Role of IgE in Crohn's Disease by Impairing the Capacity of Plasmacytoid Dendritic Cells to Generate FOXP3+ Tregs

Allergy, EarlyView.
We uncover an unprecedented role for IgE in CD. CD patients, regardless of allergic status and similar to allergic patients, display higher levels of circulating IgE+ and FcεRI+ immune cells, including pDCs, which are concomitant to fewer Tregs. In vitro experiments show that the anti‐IgE monoclonal antibody omalizumab restores the ability of pDCs from
Andrés de la Rocha‐Muñoz, Cristina Benito‐Villalvilla, David Olivares, Sofía Sirvent, Miguel A. García‐Brenes, Alba Angelina, Leticia Martín‐Cruz, Javier Cuesta, Paolo Tassinari, Xavier Jaumont, Carlos Taxonera, Oscar Palomares   +11 more
wiley   +1 more source

IA-2A positivity increases risk of progression within and across established stages of type 1 diabetes. [PDF]

Diabetologia
Sims EK, Cuthbertson D, Ferrat LA, Bosi E, Evans-Molina C, DiMeglio LA, Nathan BM, Ismail HM, Jacobsen LM, Redondo MJ, Oram RA, Sosenko JM.   +11 more
europepmc   +1 more source

Systemic lupus erythematosus caused acquired hemophilia B without evidence of factor IX inhibitors

Rheumatology &Autoimmunity, EarlyView.
Lifang Wang, Yan Ding, Lei Wang, Lianjie Shi   +3 more
wiley   +1 more source

Establishing Screening Programs for Presymptomatic Type 1 Diabetes: Practical Guidance for Diabetes Care Providers.

J Clin Endocrinol Metab
Leichter SB, Felton JL, Geno Rasmussen C, Rizzuto P, Bellini N, Ebekozien O, Schulman-Rosenbaum R.   +6 more
europepmc   +1 more source