Results 191 to 200 of about 46,324 (245)

Surface dielectric barrier discharge plasma priming enhances salt-tolerant wheat germination through predicted AMY1.1 redox stabilization. [PDF]

Sci Rep
Awaji AA, Lotfy K, El-Hashash EF, Al-Qahtani SM, El-Absy KM, Eid EA, Abo-Marzoka SA.   +6 more
europepmc   +1 more source

The Role of IGF2BP3‐Mediated Immune Response Activation in Enhancing Immunotherapy of Koumine for Gastric Cancer

Cancer Science, EarlyView.
Koumine binds IGF2BP3 and promotes its proteasomal degradation, reducing m6A on EED mRNA, accelerating EED decay, lowering H3K27me3, and promoting IRF transcription, thereby restoring MHC‐I and enhancing CD8+ T cell killing. ABSTRACT Resistance to immune checkpoint blockade in gastric cancer often arises from defective antigen presentation due to MHC‐I
Qiu Hongqiang, Lin Hailing, Lou Luqi, Wang Linyao, Lin Tian, Shengjie Zhu, Zhang Dongmei, Chen Rong, Mao Yunyi, Wancai Que, Yu Cheng   +10 more
wiley   +1 more source

Molecular docking analysis of FAS II from <i>Neisseria meningitides</i> with marine phytochemicals. [PDF]

Bioinformation
Kumari P, Ranga D, Yadav P, Saini V, Kumar A.   +4 more
europepmc   +1 more source

Triggering SORL1 Expression Restricts ccRCC Progression by Inducing Ubiquitination‐Mediated c‐Myc Degradation

Cancer Science, EarlyView.
Targeted triggering of SORL1 expression through a novel MPOC delivery system could inhibit ccRCC progression through binding to TRIM22 and further promoting ubiquitination‐mediated C‐MYC degradation, thereby facilitating the inhibition of oxidative phosphorylation through transcriptional repression of ACO2 and IDH2.
Keyi Wang, Wei Song, Qi Bai, Shaoze Shen, Xiao Lu, Chenxuan Su, Shi Yang, Yidi Wang, Yu Xia, Rui Zan, Shuai Jiang, Jianming Guo   +11 more
wiley   +1 more source

SMASH: Screening Molecules Accurately on Small Hardware. Fast, user-friendly, enhanced with a machine learning virtual screening tool. [PDF]

J Mol Model
Suárez-Alonso A, Herrera-Zúñiga LD, Lozano-Espinosa M, Giacoman-Martínez A, Alarcón-Villaseñor EF, Almanza-Pérez JC, Alarcón-Aguilar FJ.   +6 more
europepmc   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

Computational Investigation of Cinnamon Phytochemicals Targeting Key Cancer Signaling Pathways: Molecular Docking, ADMET and Molecular Dynamics Simulations Analysis. [PDF]

Curr Issues Mol Biol
Raut R, Anwar S, Alromaihi RA, Alrumaihi F.   +3 more
europepmc   +1 more source

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

The FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti, Gaia Galluzzi, Mario Frezzini, Cécile Exertier, Vittorio Brufani, Gianni Colotti, Giancarlo Ruocco, Jessica Rosati, Angelo Luigi Vescovi, Daniele Narzi, Ilaria Genovese, Andrea Ilari   +11 more
wiley   +1 more source

Histopathological Assessment of IFI6- and RSAD2-DNA Aptamers in Oral Squamous Cell Carcinoma: A Preliminary Study Based on <i>In Silico</i> Analysis. [PDF]

Biomedicines
Butt DQ, Memon MA, Harun MH, Shamsuddin SH, Che Jalil NAB, Jaafar S, Arputheraj T, Ahmad B.   +7 more
europepmc   +1 more source

Toward understanding the catalytic mechanism for two classes of bacterial phospholipid N‐methyltransferases

The FEBS Journal, EarlyView.
Phospholipid N‐methyltransferases (Pmts) synthesize phosphatidylcholine in many bacteria. In this study, we compared the catalytic mechanisms of two bacterial Pmt classes: the Rhodobacter (R‐) and the Sinorhizobium (S‐) type. Representative enzymes for each class were derived from Rubellimicrobium thermophilum and Agrobacterium tumefaciens ...
Irina Shevyreva, Lena Sophie Fritsch, Leander Mika Koch, Anton Effing, Meriyem Aktas, Franz Narberhaus   +5 more
wiley   +1 more source