Results 121 to 130 of about 627,005 (317)

Introduction: Epitope mimicry as a component cause of autoimmune disease

, 2000
The causes of autoimmune diseases have yet to be fully\ud elucidated. Autoantibodies, autoreactive T cell responses,\ud the presence of a predisposing major histocompatibility\ud complex (MHC) haplotype and responsiveness to corticosteroids are features,
Davies, J. M.
core   +1 more source

A 17 Year Old With Developmental Delay Presenting With Increasing Confusion and Imbalance

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Methylmalonic acidemia is an autosomal recessive genetic disorder primarily caused by defects in methylmalonyl‐CoA mutase and cobalamin (vitamin B12) metabolism. These defects disrupt the tricarboxylic acid cycle and oxidative phosphorylation, leading to the abnormal accumulation of metabolic products such as methylmalonic acid, propionic acid,
Wei Zhao, Yingli Zhang, Hongliang Zheng
wiley   +1 more source

Disease-specific complications of chronic lymphocytic leukemia in binet stage a patients [PDF]

, 2012
Disease-specific Complications of Chronic Lymphocytic Leukemia in Binet Stage A Patients: Analysis of Immunodeficiency, Autoimmune Constellations and Infections in the CLL1-Protocol.
Kwag, Doo Young
core  

Long-Term Outcome of Otherwise Healthy Individuals with Incidentally Discovered Borderline Thrombocytopenia.

, 2006
BACKGROUND: The long-term outcome of individuals with mild degrees of thrombocytopenia is unknown. METHODS AND FINDINGS: In a prospective study conducted between August 1992 and December 2002, 260 apparently healthy individuals with incidentally ...
Sergio Amadori, Amadori, S, Osborn, J, Provan, D., Adrian C Newland, Amadori Sergio, Newland, A, Newland Adrian C, Provan Drew, Drew Provan, AMADORI, SERGIO, Stasi, R, Stasi Roberto, John Osborn, Osborn John, Provan, D, Newland, AC, Roberto Stasi   +17 more
core   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Uncovering Genetic Variation in Systemic Lupus Erythematosus Risk Variants in Indigenous Peruvians

ACR Open Rheumatology
Objective Systemic lupus erythematosus (SLE) results in worse clinical outcomes among individuals of Amerindian descent. The genetic basis for this is uncertain, and there is a significant lack of genetic research focused on Amerindian ancestry ...
Cristina M. Lanata, Richard F. Oppong, Mary K. Horton, Victor Borda, Manuel F. Ugarte‐Gil, Joanne Nititham, Eduardo Tarazona‐Santos, Timothy D. O'Connor, Heinner Guio, Lindsey A. Criswell   +9 more
doaj   +1 more source

Pituitary–Adrenal Axis and Peripheral Immune Cell Profile in Long COVID

Biomedicines
In Long COVID, dysfunction in the pituitary–adrenal axis and alterations in immune cells and inflammatory status are warned against. We performed a prospective study in a cohort of 42 patients who suffered COVID-19 at least 6 months before attending the ...
Jaume Alijotas-Reig, Ariadna Anunciacion-Llunell, Enrique Esteve-Valverde, Stephanie Morales-Pérez, Sergio Rivero-Santana, Jaume Trapé, Laura González-García, Domingo Ruiz, Joana Marques-Soares, Francesc Miro-Mur   +9 more
doaj   +1 more source

Molecular mimicry: Can epitope mimicry induce autoimmune disease?

, 1997
Mimicry of host antigens by infectious agents may induce cross-reactive autoimmune responses to epitopes within host proteins which, in susceptible individuals, may tip the balance of immunological response versus tolerance toward response and ...
Davies, J.M., Davies, J. M., Davies, Janet M., Janet M Davies   +3 more
core   +1 more source

Subclinical Optic Nerve Involvement in Radiologically Isolated Syndrome: Multimodal Detection and Diagnostic Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay, Cassandre Landes‐Château, Lydiane Mondot, Mikael Cohen, Margherita Popolo, Jérôme de Seze, Bertrand Bourre, Françoise Durand‐Dubief, Olivier Casez, Orhun H. Kantarci, Aksel Siva, Stephanie Baillif, Darin T. Okuda, Letizia Leocani   +13 more
wiley   +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro, Mackenzie Silverman, Maeve C. Lucas, Mariam M. Yousuf, Samuel T. Otey, Stella V. Gray, Brittany Jordan, Madeline D. Kahan, Latanya D. Agurs, Michelle Van Hirtum Das, Deborah Holder, Devin King, Eileen A. Quinn, Ryan Kammeyer, Michael S. Rafii   +14 more
wiley   +1 more source