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Metabolism, 2007
The past twenty years of research on leptin has provided crucial information on the link between metabolic state and immune system function. Adipocytes influence not only the endocrine system but also the immune response, through several cytokine-like mediators known as adipokines, which include leptin.
Procaccini Claudio +3 more
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The past twenty years of research on leptin has provided crucial information on the link between metabolic state and immune system function. Adipocytes influence not only the endocrine system but also the immune response, through several cytokine-like mediators known as adipokines, which include leptin.
Procaccini Claudio +3 more
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The Indian Journal of Pediatrics, 2002
Autoimmune liver disorders are inflammatory liver diseases characterised histologically by a dense mononuclear cell infiltrate in the portal tract and serologically by the presence of non-organ and liver specific autoantibodies and increased levels of immunoglobulin G (IgG), in the absence of a known etiology.
Mieli-Vergani, G, Vergani, D
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Autoimmune liver disorders are inflammatory liver diseases characterised histologically by a dense mononuclear cell infiltrate in the portal tract and serologically by the presence of non-organ and liver specific autoantibodies and increased levels of immunoglobulin G (IgG), in the absence of a known etiology.
Mieli-Vergani, G, Vergani, D
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JAMA: The Journal of the American Medical Association, 1987
SINCE the earliest descriptions of the immune system, the ability of an individual to react to a wide variety of foreign and endogenous antigens, while not responding to one's own self, has intrigued researchers. The first descriptions of autoimmune phenomena in the early 1900s aroused sufficient anxiety to cause Ehrlich to coin the term "horror ...
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SINCE the earliest descriptions of the immune system, the ability of an individual to react to a wide variety of foreign and endogenous antigens, while not responding to one's own self, has intrigued researchers. The first descriptions of autoimmune phenomena in the early 1900s aroused sufficient anxiety to cause Ehrlich to coin the term "horror ...
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Infection, autoimmunity and autoimmune disease
1996Studies of the immune response of mammals to infectious agents have revealed that members of the hsp60 and hsp 70 family are highly immunodominant. Given their high conservation during evolution this was surprising, because of the apparent risk of triggering of autoimmunity and autoimmune disease during the defense of a mammal against infection ...
U, Feige, W, van Eden
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Seronegative Autoimmune Diseases
Annals of the New York Academy of Sciences, 2009A close relationship exists between autoimmunity and autoantibodies; despite this, some patients are persistently negative for disease‐specific autoantibodies. These conditions have been defined as seronegative autoimmune diseases. Although the prevalence of seronegative autoimmune diseases is low, they may represent a practical problem because they ...
ALESSANDRI, cristiano +5 more
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Autoimmunity and Celiac Disease
Mini-Reviews in Medicinal Chemistry, 2008In celiac disease (CD), abnormal immune-mediated responses follow ingestion of gluten. Although the triggering agent is a dietary protein, the disease has autoimmune components because of the presence of autoantibodies and its association with autoimmune conditions.
GIANFRANI C +2 more
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Cancer and Autoimmune Diseases
Autoimmunity Reviews, 2017The association between autoimmunity and cancer is well established. Cancer has been implicated in some autoimmune disorders (AID), such as scleroderma and myositis. On the other hand, many autoimmune disorders and immunosuppressive therapy, have been linked to an increased risk for cancer.
Eitan, Giat +2 more
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Celiac Disease and Autoimmunity
Journal of Pediatric Gastroenterology and Nutrition, 2014ABSTRACTCeliac disease (CD) has a multifactorial etiology with complex genetics and frequently occurs in association with other autoimmune disorders. Even though triggered by a dietary antigen, it shows many autoimmune features, the most peculiar being the presence of high titers of anti‐tissue transglutaminase 2 autoantibodies, produced in the small ...
TRONCONE, RICCARDO, DISCEPOLO, VALENTINA
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Autoimmunity in Neuromuscular Disease
Annals of the New York Academy of Sciences, 1987SUMMARY AND CONCLUSIONSA number of confounding factors can be identified from the search for autoimmune mechanisms over the last 2 decades that may be relevant for future studies. (1) An apparently homogeneous clinical disorder may represent more than one disease process and thereby imply antibody/antigen heterogeneity as, for example, in MG with and ...
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Immunoregulation of Autoimmune Diseases
Human Immunology, 2006Since the discovery of human leukocyte antigen (HLA) as a genetic system, the search for the biological function of HLA molecules has been a very intense and attractive area of immunological research. It has been a major factor in the development of our understanding of the role of T cells in the initiation and regulation of autoimmune diseases.
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