Results 91 to 100 of about 401,372 (284)

Single‐cell RNA sequencing revealed the T‐cell heterogeneity and exhaustion subsets of Helicobacter pylori‐induced gastritis‐to‐cancer transformation

VIEW, EarlyView.
H. pylori infection is a major cause of stomach cancer, but its effect on immune cells in tumors is unclear. Using single‐cell sequencing, we mapped the stomach tumor environment and discovered a specific exhausted T‐cell subtype, marked by the FYB1 gene, that is abundant in H. pylori‐positive tumors and linked to patient prognosis. Our findings reveal
Yanhui Yang, Yanxia Liu, Xiaole Guo, Zhaorun Li, Ziyu Liu, Shuming Zhang, Yuma Yang, Jun Liu, Shoucheng Ma, Linke Ma, Xianmei Chen, Xue Li, Yuanyuan Tang, Xiaoling Ding, Xiaofei Li, Qian Hao, Yanjie You, Tingting Yang, Qingrui Li, Xue Zhang, Sihan Zhang, Hengjun Gao, Shengjuan Hu   +22 more
wiley   +1 more source

Clinical case of endoscopic diagnosis of autoimmune atrophic gastritis

Клинический разбор в общей медицине, 2022
Autoimmune atrophic gastritis (AIG) is a chronic progressive inflammatory disease that results in damage to the gastric parietal cells and replacement of these cells by atrophic and metaplastic mucosa.
Ivan V. Smirnov
doaj   +1 more source

Creating a Framework for Treating Autoimmune Gastritis—The Case for Replacing Lost Acid

Nutrients
Autoimmune gastritis (AIG) is characterized by the destruction of gastric parietal cells, resulting in hypochlorhydria and eventual achlorhydria, as oxyntic glands in the corpus are destroyed and become atrophic.
Lori Taylor, Andrew McCaddon, B. Wolffenbuttel   +2 more
semanticscholar   +1 more source

Examining the Diagnosis and Treatment Experiences of People Living With Autoimmune Gastritis and Pernicious Anemia

Journal of Patient Experience, 2023
There is limited research evaluating the diagnosis and treatment of patients with autoimmune gastritis (AIG) and pernicious anemia (PA). We used a 2-phase data collection process to examine the literature and individual patient accounts.
Martine Cotton, A. McCaddon
semanticscholar   +1 more source

MALT1 proteolytic activity suppresses autoimmunity in a T cell intrinsic manner [PDF]

, 2019
MALT1 is a central signaling component in innate and adaptive immunity by regulating NF-kappa B and other key signaling pathways in different cell types. Activities of MALT1 are mediated by its scaffold and protease functions.
Baens, Mathijs, Beyaert, Rudi, Demeyer, Annelies, Driege, Yasmine, Hochepied, Tino, Kreike, Marja, Skordos, Ioannis, Staal, Jens   +7 more
core   +2 more sources

Elevated beta‐hydroxybutyrate within a pediatric population and its associated pathology: A retrospective case series

Journal of Forensic Sciences, EarlyView.
Abstract Elevated beta‐hydroxybutyrate (BHB) is a marker for ketoacidosis. Post‐mortem values for the diagnosis of fatal ketoacidosis and the associated clinical and histologic findings are limited in the pediatric population. A retrospective case series of pediatric autopsy records and histology slides was conducted.
Nasim Haghandish, Anthea Girdwood, Christopher Milroy, Jacqueline Parai   +3 more
wiley   +1 more source

Histopathologic diagnosis of ultra‐early autoimmune gastritis: A case report

Clinical Case Reports, 2023
We describe an ultra‐early stage of autoimmune gastritis (AIG) that occurs prior to the well‐known early‐stage AIG. The key pathology is the shortening of the second layer with degenerated parietal cells.
S. Terao, Shiho Suzuki, R. Kushima
semanticscholar   +1 more source

Autoimmune Gastritis in the Pediatric Age: An Underestimated Condition Report of Two Cases and Review. [PDF]

, 2018
<b>Background:</b> Diagnosis of pediatric autoimmune gastritis (AIG) in children is important due to poor outcome and risk of malignancy. This condition is often underestimated in the clinico-pathologic diagnostic work-up, leading to delayed
Abdelrahman, K., Karpate, A., Nydegger, A., Saglietti, C., Schneider, V., Sciarra, A., Sempoux, C.   +6 more
core   +2 more sources

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen, Tamás Kovács, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Apeced in Turkey: a case report and insights on genetic and phenotypic variability [PDF]

, 2018
APECED is a rare monogenic recessive disorder caused by mutations in the AIRE gene. In this manuscript, we report a male Turkish patient with APECED syndrome who presented with chronic mucocutaneous candidiasis associated with other autoimmune ...
Alessandra Fierabraccia, Corrado Betterle, FRASCA, FEDERICA, Marsha Pellegrino, Sara Sebnem Kilic   +4 more
core   +1 more source