Results 31 to 40 of about 29,121 (207)

Coexistence of Immune Checkpoint Inhibitor-Induced Autoimmune Diabetes and Pancreatitis

Frontiers in Endocrinology, 2021
Autoimmune diabetes is a rare but severe endocrine toxicity induced by immune checkpoint inhibitor (ICI) treatment. It is unclear if ICI causes selective islet toxicity or non-selective pancreas toxicity.
Amy L. Zhang, Fang Wang, Lee-Shing Chang, Marie E. McDonnell, Le Min   +4 more
doaj   +1 more source

Chemokines in thyroid autoimmunity

Best Practice & Research Clinical Endocrinology & Metabolism, 2023
The chemokine receptor CXCR3 and its chemokines CXCL9, CXCL10, and CXCL11 are involved in the pathogenesis of autoimmune diseases. Th1 lymphocytes are recruited by Th1 chemokines, secreted by damaged cells. In inflamed tissues, the attracted Th1 lymphocytes induce the IFN-gamma and TNF-alpha release, that stimulates the secretion of Th1 chemokines ...
Ferrari, Silvia Martina, Paparo, Sabrina Rosaria, Ragusa, Francesca, Elia, Giusy, Mazzi, Valeria, Patrizio, Armando, Ghionzoli, Marco, Varricchi, Gilda, Centanni, Marco, Ulisse, Salvatore, Antonelli, Alessandro, Fallahi, Poupak   +11 more
openaire   +3 more sources

Cytokines in Thyroid Autoimmunity

Autoimmunity, 2003
The role of cytokines in the pathogenesis of autoimmune thyroid disease (ATD) has been extensively investigated over the past years. In patients with ATD, these molecules can be found in both the thyroid and sites of extrathyroidal complications of the disease.
R A, Ajjan, A P, Weetman
openaire   +2 more sources

Autoimmune Thyroid Disorders [PDF]

Journal of Thyroid Research, 2011
Thyroid autoimmunity, as reflected by the presence in serum of autoantibodies directed against the thyroid autoantigens thyroglobulin (Tg) and thyroid peroxidase (TPO), is present in >10% of the US population over 12 years of age [1] and is the most common cause of endocrine dysfunction in iodine-sufficient populations [2].
Brown, Rosalind, Francis, Gary L.
openaire   +4 more sources

Assessing the Sensitivity and the Clinical Impact of the 2023 American College of Rheumatology/EULAR Classification Criteria in Obstetric Antiphospholid Syndrome: Findings From a Multicenter Italian Cohort With a Long‐Term Follow‐Up

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to evaluate the sensitivity of the 2023 American College of Rheumatology (ACR)/EULAR classification criteria for antiphospholipid syndrome (APS) in a real‐world cohort of women diagnosed with primary obstetric APS (oAPS) and to assess their ability to identify patients at risk of future pregnancy complications ...
Francesca Ruffilli, Cecilia Nalli, Francesca Crisafulli, Carlo Garaffoni, Marcello Govoni, Giulia Voltarel, Alba C. Pozzi, Beatrice Maranini, Ettore Silvagni, Alessandra Bortoluzzi, Angela Tincani   +10 more
wiley   +1 more source

Targeting METTL3 Attenuates Thyroid Inflammatory Injury by Restoring Th17/Treg Balance through a YTHDC2‐m6A‐Dependent KDR/VEGFA Loop

Advanced Science, EarlyView.
METTL3‐mediated m6A modification stabilizes KDR/Kdr mRNA through YTHDC2, amplifying the VEGFA‐KDR feedback loop and disturbing Th17/Treg balance. This pathway promotes persistent inflammation and tissue damage in patients with AIT, and inhibiting the METTL3‐KDR axis effectively disrupts this circuit, alleviating thyroid tissue injury and disease ...
Qingyi Hu, Huan Liu, Anwen Ren, Zimei Tang, Jie Tan, Wen Yang, Jie Ming, Tao Huang   +7 more
wiley   +1 more source

Fine needle aspiration cytology of thyroid and its correlation with serological findings

Journal of Pathology of Nepal, 2017
Background: Thyroid autoimmunity can cause several forms of thyroid disorders i.e. Grave’s disease, Hashimoto’s thyroiditis, atrophic autoimmune thyroiditis, post-partum thyroidits etc. Cytological diagnosis may be sometimes difficult is some cases.
S Karki, A Shrestha
doaj   +1 more source

Hormonal and immunological features of autoimmune tyroiditis in persons in families with autoimmune diseases

Медицинская иммунология, 2020
Hormonal and immunological characteristics of have been studied in individuals with initial autoimmune thyroiditis who have first- and second-degree relatives with autoimmune diseases.
L. A. Bolotskaya, A. A. Tarlyun
doaj   +1 more source

From Interferon Signature to the Clinical Landscape: Type I Interferonopathies

Arthritis &Rheumatology, EarlyView.
Objective TypeI interferonopathies are heterogeneous diseases driven by dysregulated type I interferon (IFN‐I) signaling. Diagnosis is challenging due to clinical/molecular variability and the need for IFN‐I quantification. The aim of this study was to characterize the clinical, immunologic, genetic, molecular profiles of patients with suspected ...
Ismail Yaz, Seza Ozen, Hacer Neslihan Bildik, Canberk Ipsir, Dilara Unal, Saliha Esenboga, Begum Cicek, Mehmet Emin Seker, Fatima Aerts‐Kaya, Seher Sener, Mehmet Orhan Erkan, Hanife Avci, Deniz Cagdas, Ilhan Tezcan   +13 more
wiley   +1 more source

The IL-4 Level among Patients with Autoimmune Thyroiditis in Al-Najaf Governorate, Iraq

Medical Journal of Babylon
Background: The study of autoimmune thyroiditis is considered one of the challenges of sustainable development. Autoimmune thyroiditis includes largely cellular and humoral immune responses targeted at the thyroid gland, including Graves thyroiditis and ...
Sarah Hasan Kadhum Al-Huchaimi, Mahdi Hussain Alammar, Sabah N. Al-Fatlawi   +2 more
doaj   +1 more source