Results 211 to 220 of about 296,707 (334)

Type 1 Diabetes and Other Autoimmune Diseases-Epidemiology, Pathophysiology and Screening. [PDF]

Endocrinol Diabetes Metab
Kahaly GJ, Forst T, Kellerer M, Lanzinger S, Rötzer RD, Schott M, Schumm-Draeger PM.   +6 more
europepmc   +1 more source

Factors predisposing to humoral autoimmunity against brain-antigens in health and disease: Analysis of 49 autoantibodies in over 7000 subjects

, 2022
Vinícius Daguano Gastaldi, Justus B. H. Wilke, Cosima A Weidinger, Carolin Walter, Nadine Barnkothe, Bianca Teegen, Felix Luessi, W. Stöcker, Fred Lühder, Martin Begemann, Frauke Zipp, Klaus‐Armin Nave, Hannelore Ehrenreich   +12 more
openalex   +1 more source

Onion‐Mitochondria Inhibit Lipopolysaccharide‐Induced Acute Lung Injury by Shaping Lung Macrophage Mitochondrial Function

Advanced Science, EarlyView.
Proposed model of orally administered onion mitochondria (O‐Mit) uptake by lung macrophages and fuse with macrophage mitochondria (M‐Mit). This fusion reprograms the metabolism of dysfunctional M‐Mit in lipopolysaccharide‐induced murine acute lung injury by modulating dynamin‐related protein 1 (DRP1) phosphorylation and cardiolipin peroxidation ...
Qingbo Xu, Yun Teng, Yinan Huang, Jingyao Mu, Lucy Teng, Hongjia Qian, Qiming Huang, Minmin Liu, Yi Zou, Lifeng Zhang, Michael L Merchant, Xiang Zhang, Jun Yan, Huang‐Ge Zhang   +13 more
wiley   +1 more source

Endocrine polyautoimmunity: Mechanistic insights and the future of AI-driven diagnostics. [PDF]

EXCLI J
Heydarzadeh S, Abooshahab R, Zarkesh M, Hedayati M.   +3 more
europepmc   +1 more source

ENPP1 governs the metabolic regulation of effector T cells in autoimmunity by detecting cytosolic mitochondrial DNA

Huiyan Ji, Wanwan Jiang, Juan Zhang, Mengdi Liu, Danhua Su, Jiaxin Lei, Lingyi Li, Ming Zheng, Ting Liu, Zhichun Liu, Qinghua Cao, Lin Xu, Sidong Xiong, Zhenke Wen   +13 more
openalex   +2 more sources

Lymph node depots exert local control over T cell fate to durably and safely reverse myelin-driven autoimmunity 3552 [PDF]

Senta M. Kapnick, Emily A. Gosselin, Shannon J. Tsai, Robert S. Oakes, Zahra A Habibabady, Marian A. Ackun‐Farmmer, Sean T Carey, Shrey A Shah, Ruochen Shen, Christopher J. Bridgeman, Ryan A. McIlvaine, Lisa H. Tostanoski, Agnès Azimzadeh, Richard N. Pierson, Jonathan S Bromberg, Christopher M. Jewell   +15 more
openalex   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Malignancy and Autoimmune Susceptibility in Adult Patients with Human Inborn Errors of Immunity. [PDF]

J Clin Immunol
Segura-Tudela A, Nieto-López C, Bermejo-Olivera FJ, Andara LA, Arroyo-Ródenas J, Dueñas-Prieto L, Alfocea-Molina Á, Paz-Artal E, Pleguezuelo D, Cabrera-Marante O, Allende LM.   +10 more
europepmc   +1 more source

CARD9 Conveys Pancreatic Islet Sympathetic Nervous β2 Signals to Reshape Macrophage Creatine Metabolism in Type 1 Diabetes

Advanced Science, EarlyView.
This study identifies CARD9 as a key mediator linking sympathetic β2‐adrenergic receptor signaling to macrophage creatine metabolism, inflammatory polarization, and neuronal integrity. Loss of β2‐AR‐PKA‐CREB1‐CARD9 signaling in macrophages reduces creatine uptake, promotes pro‐inflammatory macrophage activation, and drives sympathetic axon ferroptosis.
Huimin Yuan, Senlin Li, Shuai Liu, Hong Zhou, Yue Xu, Wenhui Li, Mengxuan Wang, Mengheng Wang, Mengzhu Zheng, Wenxi Shi, Xin Li, Yiting Feng, Ming Xiang   +12 more
wiley   +1 more source

Immunopathogenesis of Systemic Lupus Erythematosus: Interplay of Innate and Adaptive Immunity, Microbiome Dysbiosis, and Emerging Therapeutic Targets. [PDF]

Pathophysiology
Ahmed A, Li S, Yu JJ, Shao WH.
europepmc   +1 more source