Results 51 to 60 of about 4,410 (179)

Epinephrine auto-injector needle length

Allergy, Asthma & Clinical Immunology, 2020
Background Epinephrine auto-injectors are expected to deliver the drug intramuscularly. Objective To study whether injection through clothing influences the frequency of subcutaneous and intraosseous/periosteal deposition of epinephrine.
Sten Dreborg, Gina Tsai, Harold Kim
doaj   +1 more source

Clinical Pharmacology of Eplontersen, the First Approved GalNAc‐Conjugated Antisense Oligonucleotide

The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.
Abstract Eplontersen is a GalNAc‐conjugated antisense oligonucleotide (ASO) approved for the treatment of hereditary transthyretin‐mediated amyloidosis with polyneuropathy (ATTRv‐PN). GalNAc conjugation enables targeted hepatic delivery and improved potency compared with unconjugated ASOs.
Rosie Z. Yu, John K. Diep, Xiang Gao, Cecilia Arfvidsson, Angelica Quartino   +4 more
wiley   +1 more source

Efficacy and safety of secukinumab administration by autoinjector in patients with psoriatic arthritis: results from a randomized, placebo-controlled trial (FUTURE 3)

Arthritis Research & Therapy, 2018
Background The study aimed to assess 52-week efficacy and safety of secukinumab self-administration by autoinjector in patients with active psoriatic arthritis (PsA) in the FUTURE 3 study (ClinicalTrials.gov NCT01989468).
Peter Nash, Philip J. Mease, Iain B. McInnes, Proton Rahman, Christopher T. Ritchlin, Ricardo Blanco, Eva Dokoupilova, Mats Andersson, Radhika Kajekar, Shephard Mpofu, Luminita Pricop, on behalf of the FUTURE 3 study group   +11 more
doaj   +1 more source

Stability of oxycodone in compound sodium lactate

Journal of Pharmacy Practice and Research, Volume 56, Issue 4, Page 306-313, August 2026.
Abstract Background It is sometimes clinically desirable to administer oxycodone concurrently with compound sodium lactate via the same intravenous (IV) line; however, there are limited stability and compatibility data for this combination. Aim To determine the stability of oxycodone in compound sodium lactate IV solution.
The‐Phung To, Michael Ching, Philip Zeglinski, Ljubica Trajceska, Yvonne Lau, Kate Schimmelbusch, Kent Garrett   +6 more
wiley   +1 more source

Systematic literature review of asthma biologic self-administration enhanced by a patient perspective

Journal of Allergy and Clinical Immunology: Global
Background: Several biologics for the treatment of severe asthma are available as self-administration devices. Objective: We performed a systematic literature review to understand the use, benefits, and challenges of these self-administration devices ...
Simona Boccaletti, MSc, Rafael Alfonso-Cristancho, PhD, Waseem Ahmed, MBA, Lehanne Sergison, Adaeze Eze, MSc, Prashant Auti, MS (Pharm), Cathelijne Alleman, MSc, Lohit Badgujar, PhD, Nicholas Halfpenny, MSc, Dorothea Heldt, MSc   +9 more
doaj   +1 more source

International Guideline on the Diagnosis and Management of Pediatric Patients With Hereditary Angioedema

Allergy, Volume 81, Issue 8, Page 2744-2774, August 2026.
ABSTRACT Hereditary angioedema (HAE) with C1 inhibitor deficiency is a rare disease characterized by unpredictable episodes of tissue swelling (angioedema), which, in most cases, occur first under the age of 18 years, and entail a significant burden of disease not only for the patients but also for their families.
Henriette Farkas, Inmaculada Martinez‐Saguer, Konrad Bork, Anastasios E. Germenis, Anete S. Grumach, Hanga Réka Horváth, Andrea Luczay, Andrea Zanichelli, Markus Magerl, Stephen Betschel, Emel Aygören‐Pürsün, Jonathan A. Bernstein, Isabelle Boccon‐Gibod, Teresa Caballero, Mauro Cancian, Sandra Christiansen, Danny M. Cohn, Francisco Contreras, Sansanee Craig, Camelia Isaic, Ankur Jindal, Constance H. Katelaris, Hilary J. Longhurst, Andrew MacGinnitie, Jonny Peter, Grzegorz Porebski, Avner Reshef, Dinh Van Nguyen, Bruce Zuraw, Anthony J. Castaldo, Henrik Balle Boysen, Timothy Craig, the Hereditary Angioedema Working Group (HAWK Group), Adil Adatia, Fiorella Adrianzen, Shimalee Andarawewa, Sladjana Andrejevic, Gabriel Emmanuel Arce‐Estrada, Ecem Ay, Adil Bahadir, Noemi Anna Bara, Marko Barešić, Krasimira Baynova, Shira Benor, Juliette Besson, Dharmagat Bhattarai, Patricia Bigas, Alexis Bocquet, Laurence Bouillet, Nicholas Brodszki, Thomas Buttgereit, Rosario Cabañas, Regis Campos, Asuman Çamyar, Orlane Chol, Stefan Cimbollek, Monica Colque Bayona, Cascia Day, Mats de Lange, Alex Fam, Davide Firinu, Tomas Freiberger, Johana Gil‐Serrano, Delphine Gobert, Dawn Goodyear, Maria del Mar Guilarte Clavero, Svetlana Hadvabova, David Hagin, Roman Hakl, George Harmat, Mensuda Hasanhodzic, Gocki Jacek, Joshua Jacobs, Rashmi Jain, Milos Jesenak, Amin Kanani, Daniela Kapustová, Boris Karanovic, Paul Keith, Tamar Kinaciyan, Pavlina Kralickova, Marcin Kurowski, Krzysztof Kuziemski, Rolando Laurel‐Laurel, Iris Leibovich‐Nassi, Gabriela Leon Zambrana, Ramon Lleonart, Lorena Lorenzo, Ferhat Maksudov, Ania Manson, Dusanka Markovic, Jayne McGucken, Nihal Mete Gokmen, Radovan Mijanovic, Vania Maria Miranda Saavedra, Irene Modestou, Sandra Nieto, Nora Nilsson, Patrik Nordenfelt, Francesca Perego, Angelica Petraroli, Elsa Phillips‐Angles, Alicia Prieto‐García, Michel Raguet, Marc Riedl, Matija Rijavec, Solange Rodrigues Valle, Yaryna Romanyshyn, Antoine Saut, Riccardo Senter, Branislav Šlenker, Marta Sobotkova, Peter J. Spaeth, Marcin Stobiecki, Linda Sundler Björkman, Mireille‐Maria Suttle, Agnes Szilágyi, Paola Triggianese, Kassiani Tzeli, Martina Vachová, Anna Valerieva, Solange Valle, Lilian Varga, Walter A. Wuillemin, Patrick Yong, Zhi Yuxiang, Liudmyla Zabrodska, Radana Zachova, Julia Zharankova   +128 more
wiley   +1 more source

Human factors validation study of 3 mg sumatriptan autoinjector, for migraine patients

Medical Devices: Evidence and Research, 2016
Elimor Brand-Schieber,1 Sagar Munjal,1 Rajesh Kumar,1 Anthony D Andre,2 Will Valladao,2 Margarita Ramirez2 1Dr. Reddy’s Laboratories Inc., Princeton, NJ, 2Interface Analysis Associates, Saratoga, CA, USA Background: Migraine pain relief is reported
Brand-Schieber E, Munjal S, Kumar R, Andre AD, Valladao W, Ramirez M   +5 more
doaj  

The effect of mepolizumab dosage form on treatment outcomes in severe asthma

Frontiers in Medicine
BackgroundA monoclonal antibody such as mepolizumab typically first appears as a parenteral lyophilized formulation (LYO), then as various parenteral solution forms, and finally as a self-administered form at homecare.
Martina Vetchá, Kateřina Kubová, Constantinos Glynos, Sylvie Pavloková, Irena Krčmová, Irena Krčmová, Eva Voláková, Eva Voláková, Ondřej Fibigr, Ondřej Fibigr, Beáta Hutyrová, Beáta Hutyrová, Alena Vlachová, Jiří Zeman, David Vetchý   +14 more
doaj   +1 more source

Comparison between prefilled syringe and autoinjector devices on patient-reported experiences and pharmacokinetics in galcanezumab studies

Patient Preference and Adherence, 2018
Virginia L Stauffer,1 Ryan Sides,1 Michel Lanteri-Minet,2,3 William Kielbasa,1 Yan Jin,1 Katherine J Selzler,1 Stewart J Tepper4 1Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA; 2Pain Department, CHU Nice, Nice, France ...
Stauffer VL, Sides R, Lanteri-Minet M, Kielbasa W, Jin Y, Selzler KJ, Tepper SJ   +6 more
doaj  

Improving adrenaline autoinjector adherence: A psychologically informed training for healthcare professionals

Immunity, Inflammation and Disease, 2019
Background Clinicians draw on instructional approaches when training patients with anaphylaxis to use adrenaline autoinjectors, but patient use is poor.
Béré Mahoney, Elaine Walklet, Eleanor Bradley, Steve O'Hickey   +3 more
doaj   +1 more source