Results 71 to 80 of about 244,822 (281)

New insights into applications of base editor in hereditary disorders

Interdisciplinary Medicine, EarlyView.
Abstract Hereditary disorders are a group of diseases caused by genetic mutations or chromosomal variations. Although the incidence of each genetic disorder is relatively low, patients affected by the disease generally experience a range of severe symptoms, including blindness, disability, and even premature death. In addition, the available treatments
Maoping Cai, Linhui Zhang, Liqing Li, Yue Liu, Canbin Lv, Yan Shi, Jianyuan Zhao, Dingwei Ye, Yuanyuan Qu   +8 more
wiley   +1 more source

Tandem High‐Dose Chemotherapy and Autologous Stem Cell Transplantation for Osteosarcoma with Initial Pulmonary Metastases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Although the survival rates of patients with localized osteosarcoma have significantly improved, metastatic osteosarcoma still has a poor prognosis. The role of high‐dose chemotherapy and autologous stem cell transplantation (HDC/ASCT) in high‐risk osteosarcoma remains unclear compared to that of conventional chemotherapy, and an ...
Hyun Jin Park, Kyung Taek Hong, Jung Yoon Choi, Bo Kyung Kim, Han‐Soo Kim, Samina Park, Sung‐Hye Park, Jung‐Eun Cheon, Hyoung Jin Kang   +8 more
wiley   +1 more source

Preliminary exploration on operation process for autologous ozonized blood transfusion

Zhongguo shuxue zazhi, 2023
Autologous ozonized blood transfusion(AOBT) is a therapy of re-transfusion of 100-200 mL of autologous blood after shaking and agitation with appropriate amount of oxygen-ozone in vitro.
Jianjun WU, Yan BAI, Yanli BAI, Zhanshan ZHA, Jing CHEN, Yahan FAN, Jiwu GONG, Shouyong HUN, Hongbing LI, Zhongjun LI, Jiajin LIN, Chunxia LIU, Fenghua LIU, Jiubo LIU, Jingling LUO, Xianjun MA, Deying MENG, Shijie MU, Mei QIN, Hui WANG, Haiyan WANG, Qiushi WANG, Quanli WANG, Xiaoning WANG, Yongjun WANG, Changsong WU, Lin WU, Jue XIE, Pu XU, Liying XU, Mingchia YANG, Yongtao YANG, Yang YU, Zebo YU, Juan ZHANG, Xiaoyu ZHOU, Xuelian ZHOU, Shuming ZHAO   +37 more
doaj   +1 more source

Hemophilia A: An Ideal Disease for Prenatal Therapy

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemophilia A (HA) is the most common inherited coagulation defect. Current state‐of‐the‐art treatment consists of frequent administration of prophylactic infusions of coagulation factor VIII (FVIII) protein or bispecific antibodies that replace the cofactor function of FVIIIa to maintain hemostasis. However, these treatments are far from ideal,
Christopher D. Porada, Anthony Atala, Graça Almeida‐Porada   +2 more
wiley   +1 more source

Clinical, haematological and biochemical responses of sheep undergoing autologous blood transfusion

BMC Veterinary Research, 2012
BackgroundThis study aimed to evaluate the clinical, haematological and biochemical responses to autologous blood transfusion and the feasibility of this practice in sheep.
R. S. Sousa, D. Chaves, R. A. Barrêto-Júnior, I. K. Sousa, H. Soares, I. O. Barros, A. Minervino, E. Ortolani   +7 more
semanticscholar   +1 more source

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

Autologous Blood Reinfusion in Patients Undergoing Bilateral Total Hip Arthroplasty

Journal of Orthopaedic Surgery, 2011
Purpose. To compare the rate and unit of allogeneic blood transfusion in one-stage bilateral total hip arthroplasty (THA) in patients with and without autologous blood reinfusion. Methods. Records of a consecutive series of 43 men and 33 women aged 25 to
Albert O Gee, Jonathan P Garino, Gwo-Chin Lee   +2 more
doaj   +1 more source

Effects of blood withdrawal and reinfusion on biomarkers of erythropoiesis in humans: Implications for anti-doping strategies [PDF]

, 2006
To discriminate autologous blood doping procedures from normal conditions, we examined the hematological response to blood withdrawal and reinfusion. We found that biomarkers of erythropoiesis are primarily affected in the anemic period.
Damsgaard, R, González-Alonso, J, Mortensen, SP, Munch, T, Mørkeberg, J   +4 more
core  

Clinical characteristics and temporal trends of lumbar drain use in minimally invasive resection of pituitary neoplasms

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
Abstract Objectives Appropriate scenarios of lumbar drain (LD) use in endonasal skull base surgery is an active area of investigation. However, existing data is limited. The purpose of this study is to evaluate the robustness of the NSQIP database to characterize morbidity and complications associated with LD usage concurrent to minimally invasive ...
Benjamin F. Bitner, Sina J. Torabi, Ellen M. Hong, Eric H. Abello, Khodayar Goshtasbi, Frank P. K. Hsu, Edward C. Kuan   +6 more
wiley   +1 more source

Efficacy of platelet-rich plasma as conservative treatment in orthopaedics. a systematic review and meta-analysis [PDF]

, 2018
Background. The aim of this systematic review and meta-analysis was to evaluate the benefit of platelet-rich plasma (PRP) in non-surgical orthopaedic procedures. Material and methods. We searched the Cochrane Wounds Specialized Register, CENTRAL, MEDLINE
Cruciani, Mario, Franchini, Massimo, Liumbruno, Giancarlo M, Marano, Giuseppe, Masiello, Francesca, Mengoli, Carlo, Pati, Ilaria, Pupella, Simonetta, Vaglio, Stefania, Veropalumbo, Eva   +9 more
core   +1 more source