Results 61 to 70 of about 1,043,302 (266)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

“Software agents and haunted media : the twitter bot as political actor" [PDF]

, 2018
This report examines the rhetorical construction of Twitter bots as nonhuman political agents in press coverage of the 2016 U.S. election. It takes the rhetorical framing of “the Twitter bot” as a case study to argue that Twitter bots are a contemporary ...
Colclough, Sarah Ansley
core   +1 more source

Automated content analysis of online political communication

, 2015
Content analysis has a long tradition in the social sciences: it is central to the study of policy preferences, propaganda and mass media, and the framing of social movements. New computational tools and the increasing availability of digitized documents promise to push forward this line of inquiry by reducing the costs of manual annotation and ...
Ross Petchler, Sandra González-Bailon
openaire   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Unmasking Machine Learning With Tensor Decomposition: An Illustrative Example for Media and Communication Researchers

Media and Communication
As online communication data continues to grow, manual content analysis, which is frequently employed in media studies within the social sciences, faces challenges in terms of scalability, efficiency, and coding scope.
Yu Won Oh, Chong Hyun Park
doaj   +1 more source

Towards cross-lingual alerting for bursty epidemic events [PDF]

, 2011
Background: Online news reports are increasingly becoming a source for event based early warning systems that detect natural disasters. Harnessing the massive volume of information available from multilingual newswire presents as many challenges as ...
Collier, Nigel
core   +5 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Intermedia Agenda-Setting in a Policy Reform Debate

International Journal of Communication, 2019
This study investigates intermedia agenda-setting dynamics between traditional news media and social media in a policy reform debate. Whereas the role of traditional news media in public debates is generally acknowledged, the growth of social media ...
Linda van den Heijkant, Martine van Selm, Iina Hellsten, Rens Vliegenthart   +3 more
doaj   +2 more sources

A critical assessment of automatic photoelastic methods for the analysis of edge residual stresses in glass [PDF]

, 2014
The measurement of residual stresses is of great importance in the glass industry. The analysis of residual stresses in the glass is usually carried out by photoelastic methods since the glass is a photoelastic material.
AJOVALASIT, Augusto, PETRUCCI, Giovanni, SCAFIDI, Michele   +2 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source