Results 41 to 50 of about 25,598,483 (300)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Fusing 4D modeling and laser scanning for automated construction progress control [PDF]

, 2010
The construction industry remains one of the riskiest of all. This risk is mainly the result of a poorly controlled, and thus uncertain, environment. For instance, construction progress is often improperly controlled, resulting in some unnoticed errors ...
Bosche, Frederic Nicolas, Haas, Carl T., Turkan, Yelda, Haas, Ralph   +3 more
core  

Pressure Control of Electro-Hydraulic Servovalve and Transmission Line Effect

Al-Khawarizmi Engineering Journal, 2013
The effected of the long transmission line (TL) between the actuator and the hydraulic control valve sometimes essentials. The study is concerned with modeling the TL which carries the oil from the electro-hydraulic servovalve to the actuator.
Jafar Mehdi Hassan, Yiqin Xue, Majid Ahmed Oleiwi, Ahmed Fouad Mahdi   +3 more
doaj  

Application of Computer Image Technology in Automated Liquid Filling Machine

Chemical Engineering Transactions, 2017
In order to better study working demands of automated filling machine, this paper bases on computer vision technology, puts forward the positioning method for detecting center coordinate at the mouth of material bucket by using computer vision technology,
Qijun Gong
doaj   +1 more source

IDENTIFICATION OF MATHEMATICAL MODEL OF TURBINE GENERATOR UNIT IN PRESENCE OF UNCERTAINTY

Технічна електродинаміка, 2021
An identification procedure of mathematical model of turbine generator unit in the presence of uncertainty is studied for using in the interconnected robust control automated system. The procedure is based on “worst-case” identification approach.
С.М. Балюта, П.О. Черненко, Ю.В. Куєвда, В.П. Куєвда   +3 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

A new concept drilling hoisting systems rigs [PDF]

Acta Montanistica Slovaca, 2006
In rig constructions two nev designs have been introduced apart from the conventional hoisting system. The first one is the Maritime Hydraulics A.S RamRig© drilling concept, based on hydraulic cylinders as actuators powered by up to 3.4 MW of hydraulic ...
Jan Artymiuk
doaj  

Design and Implementation of the Automatic Assessment System for the Command and Control Specialty in Ships

MATEC Web of Conferences, 2017
On the basis of analyzing the actual demand of automated assessment system for the command and control specialty in ships, the thought of the overall design of automated assessment system for the command and control specialty in ships is given, and the ...
Zhang Hao, Wang Zheng-yi, Yin Wei
doaj   +1 more source