Results 91 to 100 of about 2,256,813 (334)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
IEEE AccessThis paper attempts to solve the problem of identifying the critical factors of road design on human driver (HD) accidents and automated vehicle (AV) failures.
Soomin Woo +3 more
doaj +1 more source
Is Drivers' Situation Awareness Influenced by a Fully Automated Driving Scenario? [PDF]
, 2009 This paper presents results from a study conducted for the European FP6 project CityMobil. The experiment described here is part of four cross-site experiments designed to study the human factors issues associated with various degrees of automated ...
Jamson, AH, Merat, N
core
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
VIENA2: A Driving Anticipation Dataset
, 2018 Action anticipation is critical in scenarios where one needs to react before the action is finalized. This is, for instance, the case in automated driving, where a car needs to, e.g., avoid hitting pedestrians and respect traffic lights.
A Pentland +8 more
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
REHEARSE-3D: A Multi-Modal Emulated Rain Dataset for 3D Point Cloud De-Raining
SensorsSensor degradation poses a significant challenge in autonomous driving. During heavy rainfall, interference from raindrops can adversely affect the quality of LiDAR point clouds, resulting in, for instance, inaccurate point measurements.
Abu Mohammed Raisuddin +6 more
doaj +1 more source
Improving Automated Driving through Planning with Human Internal States
, 2020 This work examines the hypothesis that partially observable Markov decision process (POMDP) planning with human driver internal states can significantly improve both safety and efficiency in autonomous freeway driving.
Kochenderfer, Mykel, Sunberg, Zachary
core
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source