Results 81 to 90 of about 1,501,850 (327)

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Knowledge-Based Decision Support in Healthcare via Near Field Communication

Sensors, 2020
The benefits of automatic identification technologies in healthcare have been largely recognized. Nevertheless, unlocking their potential to support the most knowledge-intensive medical tasks requires to go beyond mere item identification.
Giuseppe Loseto, Floriano Scioscia, Michele Ruta, Filippo Gramegna, Saverio Ieva, Agnese Pinto, Crescenzio Scioscia   +6 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

A String of Pearls: Proofs of Fermat's Little Theorem

Journal of Formalized Reasoning, 2013
We discuss mechanised proofs of Fermat's Little Theorem in a variety of styles, focusing in particular on an elegant combinatorial ``necklace'' proof that has not been mechanised previously.What is elegant in prose turns out to be long-winded ...
Hing Lun Chan, Michael Norrish
doaj   +1 more source

Run-time risk management in adaptive ICT systems [PDF]

, 2013
We will present results of the SERSCIS project related to risk management and mitigation strategies in adaptive multi-stakeholder ICT systems.
Chakravarthy, Ajay, Chen, Xiaoyu, Melas, Panos, Nasser, Bassem, Surridge, Mike   +4 more
core   +1 more source

The ACCEPTance of automation: refining circulating tumor cells enumeration for improved metastatic colorectal cancer prognosis

Molecular Oncology, EarlyView.
This study highlights the potential of automated enumeration using the ACCEPT software to refine circulating tumor cell (CTC) detection in metastatic colorectal cancer (mCRC). The automated method demonstrates improved accuracy and reduced variability compared to the manual approach.
Michela De Meo, Marco Siringo, Alessandro Vici, Ann Zeuner, Orietta Gandini, Paola Gazzaniga, Chiara Nicolazzo   +6 more
wiley   +1 more source

Fast and Precise Symbolic Analysis of Concurrency Bugs in Device Drivers [PDF]

, 2015
© 2015 IEEE.Concurrency errors, such as data races, make device drivers notoriously hard to develop and debug without automated tool support. We present Whoop, a new automated approach that statically analyzes drivers for data races.
Deligiannis, P, Donaldson, AF, Rakamaric, Z   +2 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Detection of misbehaving individuals in social networks using overlapping communities and machine learning

Journal of King Saud University: Computer and Information Sciences
Detecting misbehavior in social networks is essential for maintaining trust and reliability in online communities. Traditional methods of identification often rely on individual attributes or structural network properties, which may overlook subtle or ...
Wejdan Alshlahy, Delel Rhouma
doaj   +1 more source