Results 31 to 40 of about 99,927 (260)

Editorial

open access: yesCanadian Journal of Learning and Technology, 2023
In this issue of the Canadian Journal of Learning and Technology, evidence-based practice continues to be emphasized, in addition to providing information reflecting trends in a rapidly evolving education space.
Martha Cleveland-Innes
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

MC-SleepNet: Large-scale Sleep Stage Scoring in Mice by Deep Neural Networks

open access: yesScientific Reports, 2019
Automated sleep stage scoring for mice is in high demand for sleep research, since manual scoring requires considerable human expertise and efforts. The existing automated scoring methods do not provide the scoring accuracy required for practical use. In
Masato Yamabe   +5 more
doaj   +1 more source

Automated Scoring of Creative Achievement

open access: yesThe Journal of Creative Behavior
ABSTRACT The assessment of creative achievement (CA) can be cumbersome as participants are typically asked to respond to long lists of possible accomplishments that may still miss their very specific achievements.
Noah Meinzer   +3 more
openaire   +1 more source

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

open access: yesFEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring   +3 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Automated versus human scoring of the Rey-Osterrieth Complex Figure Test: a rapid review

open access: yesFrontiers in Psychiatry
IntroductionDespite digital advances in healthcare, clinical neuropsychology has been slow to adopt automated assessment tools. Automated scoring of the Rey-Osterrieth Complex Figure Test (ROCFT) could enhance efficiency and consistency in evaluating ...
Sander Lindholm Andersen   +4 more
doaj   +1 more source

A Systematic Quality Scoring Analysis to Assess Automated Cardiovascular Magnetic Resonance Segmentation Algorithms

open access: yesFrontiers in Cardiovascular Medicine, 2022
BackgroundThe quantitative measures used to assess the performance of automated methods often do not reflect the clinical acceptability of contouring. A quality-based assessment of automated cardiac magnetic resonance (CMR) segmentation more relevant to ...
Elisa Rauseo   +29 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

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