Results 111 to 120 of about 23,073,288 (221)

Selective modulation of NaV channel gating counteracts aberrant hyperexcitability and rescues motor function and survival in a model of spinal muscular atrophy

British Journal of Pharmacology, Volume 183, Issue 23, Page 6824-6846, December 2026.
Background and Purpose Spinal muscular atrophy (SMA) is a motor neuron disease caused by SMN1 gene loss, leading to reduced survival motor neuron (SMN) protein and progressive motor neuron degeneration. Although SMN‐restoring therapies improve outcomes, residual disease burden and non‐curative efficacy underscore the need for complementary treatments ...
Fernanda C. Cardoso, Jessica A. I. Muller, Yougang Zhang, Jean Giacomotto   +3 more
wiley   +1 more source

A Natural Language-Based Automatic Identification System Trajectory Query Approach Using Large Language Models

ISPRS International Journal of Geo-Information
The trajectory data collected by an Automatic Identification System (AIS) are an essential resource for various ships, and effective filtering and querying approaches are fundamental for managing these data.
Xuan Guo, Shutong Yu, Jinxue Zhang, Huanyu Bi, Xiaohui Chen, Junnan Liu   +5 more
doaj   +1 more source

AI Alignment Versus AI Ethical Treatment: 10 Challenges

Analytic Philosophy, Volume 67, Issue 4, Page 309-327, December 2026.
ABSTRACT A morally acceptable course of AI development should avoid two dangers: creating unaligned AI systems that pose a threat to humanity and mistreating AI systems that merit moral consideration in their own right. This paper argues these two dangers interact and that if we create AI systems that merit moral consideration, simultaneously avoiding ...
Adam Bradley, Bradford Saad
wiley   +1 more source

AgentMol: Multi-Model AI System for Automatic Drug-Target Identification and Molecule Development

Methods and Protocols
Drug discovery remains a time-consuming and costly process, necessitating innovative computational approaches to accelerate early stage target identification and compound development. We introduce AgentMol, a modular multimodel AI system that integrates large language models, chemical language modeling, and deep learning–based affinity prediction to ...
Piotr Karabowicz, Radosław Charkiewicz, Alicja Charkiewicz, Anetta Sulewska, Jacek Nikliński   +4 more
openaire   +2 more sources

Triage Performance of FAM19A4/miR124‐2 Methylation: 18‐Month Follow‐Up Results From a Prospective Observational Study Within the Dutch Primary HPV‐Based Cervical Screening Program

International Journal of Cancer, Volume 159, Issue 10, Page 2463-2472, 15 November 2026.
ABSTRACT DNA methylation analysis of the genes FAM19A4 and miR124‐2 has emerged as a promising triage strategy for high‐risk (hr) human papillomavirus (HPV)‐positive women in cervical screening. This study reports a prospective evaluation of the diagnostic accuracy of FAM19A4/miR124‐2 methylation in a large population‐based primary HPV‐based screening ...
Lisanne Verhoef, Mila S. Griffioen, Maaike C. G. Bleeker, John W. J. Hinrichs, Albert G. Siebers, Albertus T. Hesselink, Chris J. L. M. Meijer, Renske D. M. Steenbergen, Johannes Berkhof, Daniëlle A. M. Heideman   +9 more
wiley   +1 more source

A Low Cost Automatic Identification System for Small Vessel Monitoring

, 2016
There is a growing need to develop a maritime surveillance capability for safety and security for small vessels on the local front. The automatic identification system (AIS) can improve ship traffic monitoring in the open seas.
N. Osman Ali, M. I. Mamat, S. Abd. Rahman, UniKL MSI, N. Hassan, S. Shaharuddin, Ir. Hj. S. Hassan, N. Othman, H. F. Hassan   +8 more
core  

AIS Assisted Identification and Refocussing of Ships in Airborne SAR Images [PDF]

, 2018
The Automatic Identification System (AIS) was established as a cooperative system for maritime surveillance, collision avoidance and combating illegal fishery. However, violations of AIS regulations need to be identified by independent sensors.
van Kempen, Michel, Scheiber, Rolf
core  

Comprehensive Assessment of Arterial, Tissue, and Venous Collaterals for Evaluating the Infarct Growth Rate: The Multimodal Collateral Score

Annals of Clinical and Translational Neurology, Volume 13, Issue 11, Page 2258-2267, November 2026.
ABSTRACT Background Collaterals are crucial factors that influence the infarct growth rate (IGR). We aimed to determine whether a comprehensive multimodal collateral score (MCS), incorporating collateral assessment at the arterial, tissue, and venous levels, is associated with functional independence and provides incremental prognostic value over ...
Giorgio Busto, Umberto Pensato, Ilaria Casetta, Giorgio U. Marcello, Angelo Barra, Anna Poggesi, Edoardo Carlesi, Sara Mancini, Andrea Ginestroni, Vittorio Miele, Alessandro Padovani, Andrea Morotti, Enrico Fainardi   +12 more
wiley   +1 more source

Synthetic polymer nanocarrier enhances dsRNA stability but not RNAi efficacy in Brassicogethes aeneus

Pest Management Science, Volume 82, Issue 11, Page 10615-10624, November 2026.
Experimental setup for dsRNA feeding in Brassicogethes aeneus to evaluate the effect of a synthetic polymer nanocarrier on RNAi efficiency. The experiment assessed whether the nanocarrier enhances RNAi after oral dsRNA delivery. (a) Stability of dsRNA–nanocarrier complexes was tested in simulated gut conditions. (b) Gene expression of αCOP and dre4 was
Triin Kallavus, Liina Soonvald, Iris Callewaert, Ana Isabel Silva, Ericmar Ávila Dos Santos, Silva Vilumets, Riina Kaasik, Sven Vereecken, Lenny Van Daele, Peter Dubruel, Jonathan Willow, Clauvis Nji Tizi Taning, Kristof De Schutter, Eve Veromann   +13 more
wiley   +1 more source

Defining High‐Impact AI in Autonomous Shipping: Legal Frameworks, Supply Chain Resilience, and Maritime Safety Dimensions

Transportation Journal, Volume 65, Issue 4, Autumn 2026.
ABSTRACT The rapid emergence of Maritime Autonomous Surface Ships (MASS) has made the governance of artificial intelligence systems a question of immediate regulatory urgency. The European Union's Artificial Intelligence Act (2024) and the Republic of Korea's AI Framework Act (2025) are the first two horizontal, binding, risk‐tiered AI statutes in ...
Sihyun Kim, Tae Jung Park
wiley   +1 more source