Results 31 to 40 of about 111,951 (217)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Applied Sciences, 2023 Efficient greenhouse production has a great supporting role in the development of vegetable agricultural and sideline product processing. In this paper, a simplified automatic transplanting device was designed and evaluated in a laboratory.
Luhua Han +5 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Plant, Soil and Environment, 2012 Solution culture experiments were conducted and the protons released were measured with an automatic titration system to determine the main factors affecting proton release by tea roots.
Q. Wan, R.K. Xu, X.H. Li
doaj +1 more source
Journal of Manufacturing and Materials Processing, 2023 The interfacial adhesion, friction, and resulting tool-part interaction during composites manufacturing contribute to the formation of residual stresses and process-induced deformations (PIDs).
Caleb Schoenholz +5 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
ODIN112–AI-Assisted Emergency Services in Romania
Applied Sciences, 2023 The evolution of Natural Language Processing technologies transformed them into viable choices for various accessibility features and for facilitating interactions between humans and computers. A subset of them consists of speech processing systems, such
Dan Ungureanu +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Jixie chuandong, 2020 The power-release function of the vehicle latch is the physical basis for passengers' non-physical operation mode to enter the vehicle and plays a vital role in the intelligent automatic door system. Aiming at the demand of dual branch chains cooperative
Bai Lele +7 more
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