Results 121 to 130 of about 7,489 (214)

Transcription and cohesin direct domain boundary spatial positioning and are linked to Friedreich's ataxia. [PDF]

Mol Cell
Karnay A, Linares-Saldana R, Wang Q, Gardner Z, Liang JA, Santini GT, Haridhasapavalan KK, Nguyen SC, Hugelier S, Shewale B, Kanemaki MT, Napierala JS, Napierala M, Wilson RB, Dubois N, Poleshko A, Kim W, Shah PP, Lakadamyali M, Joyce EF, Jain R.   +20 more
europepmc   +1 more source

The Nuclear Receptor Testicular Receptor 4 Orchestrates Cytoskeletal Organization in a G Protein Subunit Alpha 12/Rho‐Associated Protein Kinase–Dependent Manner to Promote Myofibroblast Differentiation and Tissue Fibrosis in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Members of the superfamily of nuclear receptors have been implicated in inflammatory processes and pathologic tissue remodeling and have emerged as attractive targets for pharmaceutical intervention. However, the role of testicular receptor 4 (TR4; or Nr2c2) in fibroblast activation and rheumatologic diseases has not yet been investigated ...
Yun Zhang, Lichong Shen, Junhui Zheng, Gisela Baur, Dilidaer Yasen, Honglin Zhu, Yi‐Nan Li, Xianyi Meng, Thuong Trinh‐Minh, Tim Filla, Debomita Chakraborty, Andrea‐Hermina Györfi, Christina Bergmann, Adam Reich, Alexander Kreuter, Georg Schett, Jörg H. W. Distler   +16 more
wiley   +1 more source

Gilberti project and the creation of a linguistic dataset: Conservation and linguistic study of the P'urhépecha language. [PDF]

Data Brief
Zavala AJ, González-Avilés M, Campuzano HS.   +2 more
europepmc   +1 more source

Human Fibroblast–Myeloid Cell Tissue Atlas Across the Lungs, Synovium, Skin, and Heart

Arthritis &Rheumatology, EarlyView.
Objective The availability of single‐cell RNA sequencing (scRNAseq) data in different tissues and disease states provides an opportunity to compare cellular subsets and identify common and unique cellular activation. In this study, we aimed to characterize shared and tissue‐specific myeloid and stromal phenotypes and to uncover key cellular subtypes ...
Lucy MacDonald, Katerina Apostolopoulou, Olympia Hardy, Melpomeni Toitou, Gabriela Kania, Przemyslaw Blyszczuk, Raphael Micheroli, Thomas D. Otto, Mariola Kurowska‐Stolarska, Caroline Ospelt   +9 more
wiley   +1 more source

Demographic and Acoustic Factors related to Automatic Speech Recognition Inaccuracies for Child African American English Speakers. [PDF]

Perspect ASHA Spec Interest Groups
Fletcher BN, Hsu WW, Novak VD, Wilkens ME, Hobek AW, Pratt AS, Leon M, Harrell K, McKenna VS.   +8 more
europepmc   +1 more source

Student perspectives on AI‐supported formative assessment in pharmacology

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims High‐quality feedback is crucial for helping medical students understand and apply core concepts of pharmacology, yet personalized feedback is resource‐intensive to produce. Artificial intelligence (AI) offers a potential solution, but little is known about students' perspectives on AI‐generated feedback.
Jon Andsnes Berg, Øyvind Repstad, Trond Trætteberg Serkland, Tiril Egset Mork, Christian Bru, Olav Tenstad, Monika Kvernenes   +6 more
wiley   +1 more source

Launching an independent research laboratory in a digital era: practical lessons for early career investigators. [PDF]

NPP Digit Psychiatry Neurosci
Rabinak CA.
europepmc   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Dockground: Expanding the Resource to Protein-DNA Complexes. [PDF]

J Mol Biol
Collins KW, Copeland MM, Kundrotas PJ, Vakser IA.   +3 more
europepmc   +1 more source

Awareness of the Black Triangle Scheme among healthcare professionals and consumers in Australia: A mixed‐methods study exploring reporting intentions and suggested improvements

British Journal of Clinical Pharmacology, EarlyView.
Aims The Black Triangle Scheme, introduced in 2018 in Australia, does not appear to have increased the quantity of adverse drug event (ADE) reports. This study evaluated healthcare professionals' (HCPs') and consumers' awareness of the scheme, its influence on intentions for future ADE reporting, and suggested improvements.
Eyob Alemayehu Gebreyohannes, Sieta T. de Vries, Mohammed Gebre Dedefo, Oliver Frank, Myra Thiessen, Lisa Kalisch Ellett, Christopher Thornton, Renly Lim   +7 more
wiley   +1 more source