Results 181 to 190 of about 269,577 (294)

Single‐Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids

Advanced Science, EarlyView.
This study repurposes mitochondrial DNA mutations as endogenous barcodes for lineage tracing in human pluripotent stem cell‐derived organoids. Integrated with transcriptomic and spatial data, it reveals NOTCH‐mediated stromal‐progenitor crosstalk orchestrates clonal dynamics and spatial zonation during early hematopoietic development, offering a non ...
Yan Xue, Junhao Su, Yiming Chao, Lu Liu, Xinyi Lin, Yang Xiang, Mun Kay Ho, Zezhuo Su, Junyi Chen, Zhuojuan Luo, Chengqi Lin, Ruibang Luo, Theo Aurich, Jianfeng Wu, Kelvin Sin Chi Cheung, Yuanhua Huang, Joshua W. K. Ho, Ryohichi Sugimura   +17 more
wiley   +1 more source

Alkalinity enhancement with sodium hydroxide in coastal ocean waters. [PDF]

Sci Rep
Wynn-Edwards CA, Dillon WDN, Akl J, Neill C, Anderson HJ, Lim HS, Mongin M, Shadwick EH.   +7 more
europepmc   +1 more source

Engineered Small Extracellular Vesicles Targeting Tumor‐Associated Endothelial Cells to Effectively Remodel the Glioma Microenvironment

Advanced Science, EarlyView.
This study developed a novel drug delivery platform that overcomes the blood‐brain barrier in glioblastoma. By fusing IGFBP7 with small extracellular vesicles, the platform specifically targets tumor vasculature. It effectively delivers temozolomide, suppressing tumor growth at low doses.
Lingling Liu, Feiyang Xu, Zhiming Zheng, Xiaodan Yang, Fang Yang, Pei Liu, Yuankun Chen, Yunshu Yang, Junli Zhao, Peiyan Yang, Xiaojing Zheng, Xiaohong Sun, Ping Mao, Qinwen Mao, Hao Guan, Haibin Xia, Weifeng Zhang, Dan Xiao   +17 more
wiley   +1 more source

Safety evaluation in the weaving segment between minor roads and U-turns on arterial roadways. [PDF]

Sci Rep
Amani K, Boroujerdian AM, Aali M.
europepmc   +1 more source

Programmable Multifunctional Bistable Structures for Energy Transfer and Dissipation

Advanced Science, EarlyView.
Utilizing the energy conversion characteristics of asymmetric bistable beams, this study develops a programmable multifunctional system composed of multiple bistable beams for energy transfer and dissipation. The high energy density enables the system to demonstrate potential in transient scenarios such as target delivery and shock absorption ...
Xin Na, Jincong Zhang, Zhicheng Chen, Venkatarao Selamneni, Haotian Chen, Hadi Heidari, Morteza Amjadi   +6 more
wiley   +1 more source

Services for Connected, Cooperated, and Automated Mobility based on Big Data and Artificial Intelligence: The SHOW project paradigm. [PDF]

Open Res Eur
Spanos G, Siomos A, Schmidt C, Tygesen M, Salanova JM, Rodrigues F, Papadopoulos A, Antypas E, Sersemis A, Gkemou M, Lalas A, Votis K, Ayfantopoulou G, Bekiaris E, Tzovaras D.   +14 more
europepmc   +1 more source

CD3ɛ Nanobody‐Engineered Extracellular Vesicles Driving In Vivo Generation of BiTE‐Secreting CAR‐Ts for Solid Tumor Therapy With Memory Response and Minimal Immunogenicity

Advanced Science, EarlyView.
HEK‐293T‐derived CD3ε Nb‐engineered EVs to generate dual‐targeting CAR‐T cells directly in vivo. These EVs selectively deliver CAR.BiTE transgenes into T cells and reprogramed to HLA‐G/PD‐L1‐targeting effector cells with enhanced memory and persistence.
Shi‐Wei Huang, Yu‐Chuan Lin, Chih‐Ming Pan, Yeh Chen, Ming‐You Shie, Cheng‐Yu Chen, Kai‐Wen Kan, Yi‐Wen Chen, Ming‐Chao Liu, Chung‐Chun Wu, Yu‐Ting Chiang, Huai‐Ping Ho, Chen‐Yu Lin, Pei‐Ying Lin, Yu‐Han Huang, Steffany Rusli, Wan‐Yu Mao, Pei‐Wen Huang, Sin‐Ting Wang, Wan‐Chen Tsai, Ya‐Hsu Chiu, Ting‐Hsun Lin, Wan‐Ling Chiang, Che‐Kai Chang, Zi‐Lun Lai, Mei‐Chih Chen, Shao‐Chih Chiu, Der‐Yang Cho   +27 more
wiley   +1 more source

Safe system approach to preventing cyclist fatalities: safety by design for urban and rural environments. [PDF]

Inj Epidemiol
Charyk Stewart T, Pellar A, Halari M, McClafferty K, Verville P, Pickup M, Fraser D, Gilliland J, Shkrum M.   +8 more
europepmc   +1 more source

Oral Celastrol Nanomedicine Targeting Intestinal Antigen‐Presenting Cells to Effectively Mitigate Autoimmune Uveitis via Gut‐Retina Axis

Advanced Science, EarlyView.
Oral nanoCEL exhibits effective intestinal targeting of antigen‐presenting cells and restores the Th17/Treg balance in lymph nodes and spleen, ultimately protecting the blood‐retinal barrier by inhibiting peripheral immune cell infiltration and suppressing retinal glial cell activation.
Jinrun Chen, Yuqin Wu, Bofei Xu, Jiabei Hou, Yijing Li, Yuhan Hu, Yutuo Zhu, Wenqiao Zhang, Shuqi Feng, Huanting Jin, Yuchen Cheng, Yuanyuan Jin, Jianhong Zhou, Xingyi Li   +13 more
wiley   +1 more source

Risk Factors for Introduction of H5N1 Highly Pathogenic Avian Influenza Virus in Japanese Commercial Layer Farms During the 2022-2023 Epidemic: A Case-Control Study. [PDF]

Transbound Emerg Dis
Kondo S, Yamaguchi E, Hayama Y, Yamamoto T.   +3 more
europepmc   +1 more source